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It is common ground that all cells require nutrients to develop, differentiate, and maintain their inherent activities. However, the idea that cells can rapidly alter their metabolism to perform specific functions under the pressure of different microenvironments was just brought to the light. These changes are particularly important for immune cells, as they need to respond quickly to opportunistic pathogens or tissue damage and prevent their spread. The field that investigates the interplay between immunology and metabolism is so-called immunometabolism and has supported the hypothesis that all diseases have a metabolic aspect.
The 8th edition of Wolff's Headache and Other Head Pain remains the definitive reference text in the field. Our knowledge and understanding of headache and its management have changed significantly in the twenty-first century. A new international headache classification has been adopted; headache pathophysiology and genetics have advanced; and epidemiologic studies have burgeoned. We have greater insights into the diagnosis and treatment of the secondary headaches. New treatments are available for primary headache disorders, including migraine, cluster, and chronic daily headache, and our understanding and knowledge are increasing by means of ongoing trials. The 8th edition encompasses all of this new material, with all chapters updated and many new authors added.
Headache syndromes rank amongst the most common presenting symptoms in general practice and neurology, affecting up to 15% of the adult population. Part of the Oxford Textbooks in Clinical Neurology series, the Oxford Textbook of Headache Syndromes provides clinicians with a definitive resource for diagnosing and managing patients with primary and secondary forms of headaches, either as isolated complaints or as part of a more complex syndrome. Split into 7 key sections with 59 chapters, this comprehensive work discusses the scientific basis and practical management of headache syndromes in a logical format. Each chapter is written by international experts in neurology who share their research and extensive experience by providing a wealth of practical advice for use in clinical situations. In addition, all content is up-to-date and chapters incorporate discussions on the latest International Classification of Headache Disorders 3rd edition when relevant.
Vitamin D deficiency, circulating levels lower than 15 ng/ml, is an epidemic disease worldwide with more than a billion people suffering of it in the beginning of the 21-century. Besides its impact on mineral and bone metabolism, these low vitamin D levels are also associated with a diversity of non-skeletal complications, among them cardiovascular disease, diabetes mellitus, multiple sclerosis, cancer, tuberculosis, and immune system dysfunction. Chronic Kidney Disease is also a very common disease, affecting more than 10% of the world population, ranging from stage 1 to stage 5 before dialysis. Approximately 1% of the population in industrialized countries is affected by end-stage renal disease (ESRD), needing a renal replacement therapy either hemodialysis or peritoneal dialysis, and ultimately by renal transplantation. Those CKD patients are more susceptible to exhibit reduced vitamin D stocks. Consequently, more than eighty percent of CKD patients have either insufficient or deficient vitamin D levels for multiple reasons.
This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and behavioral data of the serotonin (5-HT)-dopamine (DA) interactions. Central serotonergic and dopaminergic systems play a critical role in the regulation of normal and abnormal behaviors. Moreover, recent evidence suggests that the dysfunction of the DA and 5-HT neurotransmitter systems contribute to various mental disorders including depression, schizophrenia, drug addiction and Parkinson's disease. This extremely important topic is of wide interest within the scientific community, with relevance not only to specialists but also to general practitioners and...
Bipolar disorder is a chronic and debilitating mental illness affecting a significant proportion of the world's population. It is associated with significant impairments in health-related quality of life and psychosocial functioning, and has significant illness-related morbidity and heightened mortality rates due to medical comorbidities and suicide. The management of this disorder requires a complex combination of pharmacological and psychosocial interventions which can be challenging for clinicians. Written by world experts in the field of bipolar disorder, The Treatment of Bipolar Disorder: Integrative Clinical Strategies and Future Directions provides readers with a concise and comprehen...
Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. - Covers reviews of methodology and research in all aspects of protein chemistry - Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics
This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression...) with an overview of underlying immune dysfunctions. Lastly, the ...
This comprehensive review of a complex area is as much about women as it is about schizophrenia, encompassing the biological, endocrinological, epidemiological, reproductive, psychological and social aspects of schizophrenia as experienced by women. Femaleness impacts significantly on the onset and nature of schizophrenia suffered by women: the female brain develops more rapidly than the male; estrogens produce antipsychotic effects; the female brain ages differently from the male, with a massive preponderance of female very-late-onset schizophrenia which may be related to a relative excess of dopamine D2 receptors. An international, multidisciplinary team of clinicians and mental health researchers review past and current literature, assess the sex-specific issues and evaluate their therapeutic, clinical and social implications for more appropriate and effective treatments of schizophrenia in women now and in the future. It is essential reading for all clinicians, practitioners and researchers involved with mental health and also with women's health.