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Bile Acids and Their Receptors
This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR and GPBAR1 are essential bile acid sensors that integrate the de novo bile acid synthesis with intestinal microbiota and liver metabolism, in a broader sense, BARs play a pathogenic role in the development of common human alignments including liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis.
Citizenship and Solidarity in the European Union
A serious and plural reflection about Human Rights, democracy and economy in the European Union, under the scenario of the deepest economic and social crisis of the last decades, precarious labour market and deregulation, and a growing distance between citizens and political elites. With the participation of known scholars from the EU and Brazil.
Verb Classes and Aspect
This volume offers a variety of perspectives on two of the main topics situated at the crossroads between lexical semantics and syntax, namely: (a) aspect and its correspondence with syntactic structure; and (b) the delimitation of syntactic structures from verb classes. Almost from Aristotle’s Metaphysics, it has been assumed that verbs invoke a mental image about the way in which eventualities are distributed over time. When it comes to determining time schemata, the lexical class to which the verb belongs represents a first step. Speaking about verb classes does not exclusively mean a semantic similarity; rather, verb classes exhibit a bundle of common features and thus show a set of re...
Divine Presence in Spain and Western Europe 1500–1960
This study addresses the relation of people to divine beings in contemporary and historical communities, as exemplified in three strands. One is a long tradition of visions of mysterious wayfarers in rural Spain who bring otherworldly news and help, including recent examples. Another treats the seeming vivification of religious images—statues, paintings, engravings, and photographs apparently exuding blood, sweat and tears in Spanish homes and churches in the early modern period and the revival of the phenomenon throughout Europe in the twentieth century. Of special interest is the third strand of the book: the transposition of medieval and early modern representations of the relations between humans and the divine into the modern art of photography. Christian presents a pictorial examination of the phenomenon with a large number of religious images, commercial postcards and family photographs from the first half of past century Europe.
2CO Communicating complexity
2CO COmmunicating COmplexity is the international design conference aiming at exploring languages, approaches and technologies to respond to the emerging need for making complex information accessible throught design. 2CO’s first edition (25-26 October 2013, Alghero, Italy) has gathered an international community of professionals and scholars active in this area to share experiences, points of views and methodologies, focusing on three main areas of interest: informative-animation, interactive data visualization, info-graphics. This volume collects their contributions in the three conference categories: full papers, posters and ‘junior track’ special session. Generated by a consortium of European Universities that in 2011 started collaborating on the InformAnimation project, and by fellow Universities active in visual design teaching and research, COmmunicating COmplexity aims at becoming an international reference point for research and education in the area of communicating complexity through new media.
Modern Geography
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Public Art and Museums in Cultural Districts
Museums and public art have traditionally taken significantly different approaches to customer engagement, but throughout history they have also worked together in some urban contexts, notably as landmarks of so-called cultural districts. Public Art and Museums in Cultural Districts reviews their changing interactions in many different types of cities since the Enlightenment, or even before, going back to the etymological origins of museums and monuments in classical antiquity. The type of historical enquiry presented within the volume is not intended as a total narrative, but the international study cases considered convey a global panorama of the shifting paradigms set in different periods...
