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Cancer Biology and the Nuclear Envelope
"Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many...
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Parallel Processing
Proceedings -- Parallel Computing.
The Functional Nucleus
This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.
Anticarcinogenesis and Radiation Protection 2
The dramatic decrease in the incidence of stomach cancer in industrialized countries during the past 50 years, which is yet to be fully explained, and the observation that carcinogenesis in laboratory animals can be inhibited by antioxidants, retinoids, and caloric restriction, among other influences, challenge us to press on in the search for practical means to prevent cancer. It is in relation to this goal that the studies summarized in this book have special significance. This book is based on the invited and contributed papers presented at the Third Internationai Conference on Anticarcinogenesis and Radiation Protection, held on October 15-21, 1989, in Dubrovnik, Yugoslavia. They cover a...
Oceanography and Marine Biology
Reflecting increased interest in the field and its relevance in global environmental issues, Oceanography and Marine Biology: An Annual Review, Volume 47 provides authoritative reviews that summarize results of recent research in basic areas of marine research, exploring topics of special and topical importance while adding to new areas as they arise. This volume, part of a series that regards the all marine sciences as a complete unit, features contributions from experts involved in biological, chemical, geological, and physical aspects of marine science.
Marine Geochemistry
Marine Geochemistry offers a fully comprehensive and integrated treatment of the chemistry of the oceans, their sediments and biota. The first edition of the book received strong critical acclaim and was described as ‘a standard text for years to come.’ This third edition of Marine Geochemistry has been written at a time when the role of the oceans in the Earth System is becoming increasingly apparent. Following the successful format adopted previously, this new edition treats the oceans as a unified entity, and addresses the question ‘how do the oceans work as a chemical system?’ To address this question, the text has been updated to cover recent advances in our understanding of top...
