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Monoclonal Antibodies
This book is a printed edition of the Special Issue "Monoclonal Antibodies" that was published in Antibodies
Process Modelling and Simulation
Since process models are nowadays ubiquitous in many applications, the challenges and alternatives related to their development, validation, and efficient use have become more apparent. In addition, the massive amounts of both offline and online data available today open the door for new applications and solutions. However, transforming data into useful models and information in the context of the process industry or of bio-systems requires specific approaches and considerations such as new modelling methodologies incorporating the complex, stochastic, hybrid and distributed nature of many processes in particular. The same can be said about the tools and software environments used to describ...
Biopharmaceutical Manufacturing
This volume “Cell Engineerring 11 - Biopharmaceutical Manufacturing: Progress, Trends and Challenges” is a source of the latest innovative research and technical development in biomanufacturing systems. It is organised into 2 parts: 1) Manufacturing of recombinant therapeutic proteins (e.g. therapeutic antibodies, biosimilars/biogenerics) and 2) Manufacturing aspects of cell and gene therapy. Each with selected chapters on the following topics for both up- and downstream, such as: Advanced process strategies, especially continuous manufacturing, Advanced culture techniques, especially single-use systems, Process transfer, scale-up/scale-down models, Processing advances/Manufacturing prod...
Industrial Scale Natural Products Extraction
Covering the latest technologies in process engineering, this handbook and ready reference features high pressure processing, alternative solvents and processes, extraction technologies and biotransformations -- describing greener, more efficient and sustainable techniques. The result is an expert account of engineering details from lab-scale experiments to large-scale industrial design. The major focus is on the engineering aspects of extraction with organic and supercritical solvents, ionic liquids or surfactant solutions, and is supplemented by aspects of both up- and downstream processing, biotransformation, as well as a survey of typical products in food, pharmaceutical and cosmetic applications. This is rounded off by market developments, economic considerations and regulations requirements in the field Authored by experts from leading industrial and academic institutions, this is essential reading for the hands-on scientist and office manager alike.
Bioprocess Intensification
Application of Process Intensification (PI) presents a set of radically innovative principles in process and equipment design, which can bring significant benefits in terms of process efficiency, capital and operating expenses, quality, process safety, and sustainability. Typical approaches in bioprocess intensification are the reduction of the number of production steps, continuous processing, integrated processes, and alternative energy inputs.
Handbook of Digital Twins
Over the last two decades, Digital Twins (DTs) have become the intelligent representation of future development in industrial production and daily life. Consisting of over 50 chapters by more than 100 contributors, this comprehensive handbook explains the concept, architecture, design specification and application scenarios of DTs. As a virtual model of a process, product or service to pair the virtual and physical worlds, DTs allow data analysis and system monitoring by using simulations. The fast-growing technology has been widely studied and developed in recent years. Featured with centralization, integrity and dynamics, it is cost-effective to drive innovation and performance. Many field...
Process Design, Integration, and Intensification
With the growing emphasis on enhancing the sustainability and efficiency of industrial plants, process integration and intensification are gaining additional interest throughout the chemical engineering community. Some of the hallmarks of process integration and intensification include a holistic perspective in design, and the enhancement of material and energy intensity. The techniques are applicable for individual unit operations, multiple units, a whole industrial facility, or even a cluster of industrial plants. This book aims to cover recent advances in the development and application of process integration and intensification. Specific applications are reported for hydraulic fracturing, palm oil milling processes, desalination, reactive distillation, reaction network, adsorption processes, herbal medicine extraction, as well as process control.
Biopharmaceutical Production Technology
Cost-effective manufacturing of biopharmaceutical products is rapidly gaining in importance, while healthcare systems across the globe are looking to contain costs and improve efficiency. To adapt to these changes, industries need to review and streamline their manufacturing processes. This two volume handbook systematically addresses the key steps and challenges in the production process and provides valuable information for medium to large scale producers of biopharmaceuticals. It is divided into seven major parts: - Upstream Technologies - Protein Recovery - Advances in Process Development - Analytical Technologies - Quality Control - Process Design and Management - Changing Face of Processing With contributions by around 40 experts from academia as well as small and large biopharmaceutical companies, this unique handbook is full of first-hand knowledge on how to produce biopharmaceuticals in a cost-effective and quality-controlled manner.
Production of Biofuels and Chemicals with Ultrasound
Conversion of biomass into chemicals and biofuels is an active research and development area as trends move to replace traditional fossil fuels with renewable resources. By integrating processing methods with ultrasound and microwave irradiation into biorefineries, the time-scale of many operations can be greatly reduced while the efficiency of the reactions can be remarkably increased so that process intensification can be achieved. “Production of Biofuels and Chemicals with Ultrasound” and “Production of Biofuels and Chemicals with Microwave” are two independent volumes in the Biofuels and Biorefineries series that take different, but complementary approaches for the pretreatment a...
Continuous Biomanufacturing
This is the most comprehensive treatise of this topic available, providing invaluable information on the technological and economic benefits to be gained from implementing continuous processes in the biopharmaceutical industry. Top experts from industry and academia cover the latest technical developments in the field, describing the use of single-use technologies alongside perfusion production platforms and downstream operations. Special emphasis is given to process control and monitoring, including such topics as 'quality by design' and automation. The book is supplemented by case studies that highlight the enormous potential of continuous manufacturing for biopharmaceutical production facilities.
