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This volume provides a state-of-the-art overview of the role of phospholipase A2 (PLA2) in the pathophysiology of inflammatory diseases. Our knowledge about PLA2 has increased tremendously in the last two decades and investigations of the enzyme have revealed a whole family of different gene products. A rough distinction can be made between intracellular and secretory PLA2. The involvement of PLA2 in various life-threatening inflammatory diseases as well as in carcinomas is documented by many contributions to this volume. Recently developed transgenic and knockout mouse models are a powerful new tool for PLA2 research. A number of specific inhibitors of the various PLA2s offer new therapeutic approaches to control unwanted acute and chronic inflammatory responses and to intervene in malignant diseases. Due to the enzyme’s important role in these pathophysiological processes, this update of PLA2 research will interest basic scientists, physicians, oncologists, ICU specialists and surgeons.
The NATO-Advanced Research Workshop "Esterases, Lipases and Phospholipases: From Structure to Clinical Significance" was held at the University of Bordeaux II, France from 22nd- 24th September 1993 under the Directorship of Professor Michel Clerc of the University of Bordeaux II. The meeting was organised by Hugues Chap (INSERM U 326, Toulouse, France), Georges Ferard (University of Strasbourg, France), Wolfgang Junge (University of Kiel, Germany) and Michael Mackness (University of Manchester, UK). In recent years it has become increasingly apparent that hydrolytic enzymes of the esterase, lipase and phospholipase type play central roles in the pathophysiology of many human diseases. The pu...
The preanalytical phase is an important component of Laboratory medicine and errors arising in this phase affect the validity of laboratory results. In this book physicians and clinical staff have access to valuable information about the current preanalytical variables and factors (patient preparation, sample collection, handling and processing before analysis).
Das Lehrbuch bereitet Medizinstudenten optimal auf das Prüfungsfach Laboratoriumsdiagnostik/Klinische Chemie vor. Im ersten Teil werden die wichtigsten Organ- u. Stoffwechselsysteme (wie Kohlenhydratstoffwechsel, Niere und ableitende Organsysteme, Immunsystem) hinsichtlich der diagnostischen Parameter einheitlich dargestellt. Zudem werden Praxisbeispiele einer gezielten Stufendiagnostik bei Vorliegen eines bestimmten Krankheitsverdachts an Hand sogenannter "Entscheidungsbäume" dargestellt und erläutert. Der zweite Teil gibt einen prüfungsrelevanten Überblick über die allgemeine und spezielle klinisch-chemische Analytik sowie die Präanalytik.
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Welche Laborwerte müssen bei welchen Verdachtsdiagnosen bestimmt werden? Und worauf weisen erhöhte oder erniedrigte Laborwerte hin? Abgestimmt auf den Berufsalltag bietet Ihnen das Buch alle relevanten Informationen: Teil I: Klinischer Abschnitt, die wichtigsten Verdachtsdiagnosen. Teil II: Alphabetische Liste mit über 350 Laborparametern und Funktionstests. Neu in der 2. Auflage: Kapitel zur molekulargenetischen Diagnostik Kapitel zur Diagnostik bei Transfusionen