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Archives are popularly seen as liminal, obscure spaces -- a perception far removed from the early modern reality. This examination of the central English archival system in the period before 1700 highlights the role played by the public records repositories in furnishing precedents for the constitutional struggle between Crown and Parliament. It traces the deployment of archival research in these controversies by three individuals who were at various points occupied with the keeping of records: Sir Robert Cotton, John Selden, and William Prynne. The book concludes by investigating the secretive State Paper Office, home of the arcana imperii, and its involvement in the government's intelligence network: notably the engagement of its most prominent Keeper Sir Thomas Wilson in judicial and political intrigue on behalf of the Crown.
Emerging Targets in Antibacterial and Antifungal Chemotherapy offers constructive ideas to researchers that could lead to the discovery of entirely new classes of drugs. The authors emphasize new topics rather than review work on known antibacterials and antifungals, and identify new targets--either the rate-limiting component of a biochemical pathway or a component of the pathway that is susceptible to a ``screening'' or ``rational drug design'' approach. Each chapter reviews the biochemical pathway and its place in the cellular scheme in order to place the target in perspective. The authors, a mixture of academic researchers and drug-discovery investigators in pharmaceutical companies, als...
Advances in Pharmacology and Chemotherapy
First multi-year cumulation covers six years: 1965-70.