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Within the framework of clinical internal medicine, they will gain critical knowledge of the many powerful molecular biology-based developments now so rapidly enhancing our understanding of the pathophysiology of disease, improving the feasibility and accuracy of diagnostic testing, and opening novel therapeutic avenues, including gene therapy. Readers will also gain a fuller understanding of the role played by genetic defects in a host of diseases, among them peripheral neuropathies, Alzheimer's disease, arrhythmias, leukemias and lymphomas, cystic fibrosis, hepatitis, HIV, autoimmune disorders, polycystic kidney disease, schizophrenia, affective disorders, alcoholism, Huntington's disease, and many more.
An outstanding collection of contributions from the leading auhorities in their specialties world wide.
For decades, Emery and Rimoin’s Principles and Practice of Medical Genetics has provided the ultimate source for practicing clinicians to learn how the study of genetics can be integrated into practice. Developed in parallel to the sixth edition, and featuring 174 original contributions from the many authors of the full set, this one volume work expertly condenses and synthesizes the most clinically relevant content, for convenient desk reference. Helping to bridge the gap between high-level molecular genetics and individual application, it follows the multi-volume set in encompassing scientific fundamentals, full spectrum discussion of major inherited disorders, and actionable therapies. ...
This reference provides a comprehensive overview of recent developments in basic research that are relevant to the application of retinoids for cancer prevention and treatment.;Organized in a quick-referral format by specific disease site, this book: describes the effects of retinoids on squamous differentiation in normal, pre-malignant, and malignant epithelial tissues; addresses the mechanisms by which cultured keratinocytes respond to retinoids; considers the antitumor activity of combination therapy with retinoids and cytokines; reviews the toxicity profiles of the vitamin A molecule and the synthetically derived retinoid compounds and their effects on humans; examines the use of retinoi...
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These proceedings comprise over 100 papers grouped in sections as follows: the history of photobiology; ultraviolet and ionizing radiations from molecules to cells; UV light and DNA damage repair and mutagenesis; photochemistry and photophysics; photosynthesis; phytocrome; rhodopsins; circadian rhyt
Defining Democracy reveals the history of a little-known experiment in urban democracy begun in New York City during the Great Depression and abolished amid the early Cold War. For a decade, New Yorkers utilized a new voting system that produced the most diverse legislatures in the city's history and challenged the American two-party structure. Daniel O. Prosterman examines struggles over electoral reform in New York City to clarify our understanding of democracy's evolution in the United States and the world.
Treatment of Skin Disease: Comprehensive Therapeutic Strategies has been thoroughly revised to give you the latest treatment options for dermatologic conditions. Mark G. Lebwohl, Warren R. Heymann, John Berth-Jones, and Ian Coulson present an intuitive and easy-to-use, definitive treatment reference that covers the full range of choices for each condition so that you are prepared even when your patients do not respond to primary or secondary therapies. With new chapters on today’s hot topics-methocillin-resistant staphylococcus aureus, atypical nevi, autoimmune progesterone dermatitis, and more-and new contributions from international experts, you’ll have a global and current perspective...