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Thrombotic thrombocytopenic purpura (TTP) is a rare disorder of the blood coagulation system. In most cases, a lack of the ADAMTS13 enzyme leads to an accumulation of ultra-large von Willebrand factor molecules in the plasma which, in turn, initiate the formation of microscopic thromboses in small blood vessels. TTP is a medical emergency. Timely diagnosis and urgent and effective management are vital – mortality in those untreated is in the region of 90%. The understanding of TTP pathogenesis has increased markedly in recent decades. It is now known that TTP is acquired (immunemediated) or congenital, and that the most common type – the acquired form – predominantly affects women in t...
The performance of high street retailers since 2000 has been largely responsible for keeping the UK out of deep recession and creating a platform for future growth. Who's Who in Retailing is a flagship publication for the sector, listing over 2500 senior executives.
ABC of Clinical Haematology An essential guide and introduction to the diagnosis, treatment and management of disorders across the breadth of clinical haematology Extensively revised, this 5th edition of ABC of Clinical Haematology covers all aspects of contemporary haematology, providing the basic science behind the disease and diagnostic aspects, along with up to date management. The text assumes little prior haematology knowledge, enabling clear understanding by non-experts, including medical students and nurses. Full colour illustrations and text boxes highlighting important learning points together enable more efficient reader comprehension. ABC of Clinical Haematology covers: Iron defi...
The double bass - the preferred bass instrument in popular music during the 1960s - was challenged and subsequently superseded by the advent of a new electric bass instrument. From the mid-1960s and throughout the 1970s, a melismatic and inconsistent approach towards the bass role ensued, which contributed to a major change in how the electric bass was used in performance and perceived in the sonic landscape of mainstream popular music. Investigating the performance practice of the new, melodic role of the electric bass as it appeared (and disappeared) in the 1960s and 1970s, the book turns to the number one songs of the American Billboard Hot 100 charts between 1951 and 1982 as a prime sour...
What happens when a man, dazzled like most of us by hi-tech, happy to have his suits made by robots in New York, sets out to find the meaning of life? John-Paul Flintoff's improbable and very funny book charts a journey through call centres and allotments, rat-catching and Savile Row tailors, to some kind of enlightenment. It is also a book about a man who learns how to crochet - and how you might too. John-Paul Flintoff is a bit of a one-off: a man who embarks on a spiritual pilgrimage by outsourcing his life to Bangalore, then hooks up with Mormons and Buddhists (well, Richard Gere), on a quest for truth and fulfilment. His journey is like a twenty-first century Candide, learning that life...
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