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Medical and Industrial Applications of Microfluidic-based Cell/Tissue Culture and Organs-on-a-Chip: Advances in Organs-on-a-Chip and Organoids Technologies
Recent developments in microfluidics have demonstrated enormous potential of microscale cell culture for biology studies and recognized as instrumental in performing rapid and efficient experiments on small-sample volumes. Microfluidic-based cell culture is an area of research that keeps growing and gaining importance as a prominent technology, able to link scientific disciplines with industrial and clinical applications. In particular, organotypic cell culture and its integration in microfluidic devices would enable the realization of “in vivo-like” cell microenvironment within systems that are more amenable to automation and integration. Such remarkable advancement forms the foundation...
Solid State
From musician, singer-songwriter, and internet superstar JONATHAN COULTON comes the graphic novel accompaniment (in square-bound, 10" x 10" format) to his new concept album, SOLID STATE. Two guys, connected by a name and hundreds of years, somehow stand at the end of man's beginning, and the beginning of man's end. But...it's funny? Also kind of a nightmare. But mostly funny? A funny science FACTion nightmare about the end of everything, but how that's all kind of okay. Teaming up with MATT FRACTION, the writer of SEX CRIMINALS, CASANOVA, and ODY-C; and the award-winning Spanish artist of Universe! ALBERT MONTEYS, COULTON's SOLID STATE is a tech mashup where 2001: A Space Odyssey meets Office Space and getting all we ever wanted might just be a terrible idea.
Jonathan's Song
On Christmas Eve 1914 naturalist and ecological pioneer John Muir dies in a California hospital. At the same moment three thousand miles away a baby is born in Bethlehem, Pennsylvania; his name is Lionel Johnson. In 1932 Lionel leaves his family and joins the Civilian Conservation Corps. The government gives him $5/month and sends the remaining $25 home to his family. The CCC is a program that worked. Flash forward to a hospital in Bellevue, Washington in 1997 where Lionel is in a coma. As he approaches death he mentally connects with an unhappy young woman, Kathryn O' Neill, who is attending Lehigh University in Bethlehem. Kathryn is a spoiled, Philadelphia 'princess'. The connection saves ...
Organs-on-chips
Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices. Since the physiological microenvironments in living systems are mostly microfluidic in nature, the use of microfluidic devices facilitates engineering cellular microenvironments; the microfluidic devices allow for control of local chemical gradients and dynamic mechanical forces, which play important roles in cellular viability and function. The organ-on-chip microdevices have ...
Biomaterial Based Approaches to Study the Tumour Microenvironment
The tumour microenvironment is increasingly recognized as an important contributor to cancer progression and treatment. However, most cancer studies continue to be performed in 2D tissue culture dishes that do not capture the characteristics of the tumour niche. This book provides an introduction to the rich chemical, topographical, and mechanical cues in the tumour microenvironment and then introduces readers to bioengineering strategies, including scaffold design and synthesis, chemical signalling and delivery, and co-culture, microfluidics, and organ-on-a-chip tools that can be used to mimic tumour microenvironment features. This book also includes discussion of emerging imaging methods compatible with tumour microenvironment mimicking biomaterials and discusses applications of such models in immuno-oncology, metastasis, and drug screening. Edited by two leaders in the field, this book will appeal to graduate students and researchers working in biomaterials science, chemical and biomedical engineering departments.
Snowbird
One of the most familiar North American birds, the snowbird, otherwise known as the Dark-eyed Junco, can be seen darting across forest floors, pecking at suburban birdfeeders, and foraging at the edges of parks, streams, and roads all across the continent. By one estimate, upwards of 630 million Juncos populate North America: twice the number of people living here in the U.S. No Bird Like the Snowbird: Integrative Approaches to Understanding Evolutionary Diversity in the Avian Genus Junco presents diverse expertise not just on the Dark-eyed Junco, but on the Junco genus more broadly. Collectively, the contributors draw on research, methods, and findings from organismal biology and evolutiona...
