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From Serra to Sancho
Music in the California missions was a pluralistic combination of voices and instruments, of liturgy and spectacle, of styles and functions - and even of cultures - in a new blend that was non-existent before the Franciscan friars' arrival in 1769. This book explores aesthetic, stylistic, historical, cultural, theoretical, liturgical, and biographical aspects of this repertoire. It contains a "Catalogue of Mission Manuscripts," 150+ facsimiles, translations of primary documents, and performance-ready music reconstructions.
Primary and Acquired Resistance in Lung Cancer
Lung cancer is one of the leading causes of cancer-related death worldwide with a prevalence of advanced stage in up to 70% of cases and a five-year survival reached in only 5-10% of cases. Targeted therapies and immunotherapy have greatly improved the management of patients with advanced non-small cell lung cancer (NSCLC), particularly adenocarcinoma, and current diagnostic algorithms are based on the molecular analysis of several biomarkers necessary to tailor therapy. In detail, patients harboring sensitive driver alterations within the oncogenes EGFR, BRAF, ALK, ROS1, RET and NTRK1/2/3 can be treated with approved kinase inhibitors (KIs). In addition, drugs against MET, KRAS G12C and other markers are providing interesting results across different clinical trials. Targeted therapies have greatly improved therapeutic options for NSCLC, but resistance inevitably occurs usually after one year of treatment and some patients, although harboring sensitive alterations, never respond to treatment.
The Ambassadress
None
Future Impacts of Biotechnology on Agriculture, Food Production and Food Processing
Although the first Agro-Food products based on modem biotechnology (e. g. recombinant chymosin for cheese production; tomato puree based on genetically engineered tomatoes; herbicide-resistant, genetically modified soybean; insect resistant maize) have been introduced in the EU markets in recent years, the application of this technology is still being intensively discussed in the European Union. Recent opinion polls indicate as well that consumers' acceptance of genetically engineered food and agro-products still is relatively low (e. g. European Commission 1997, Hampel et al. 1997), at least in some member states of the EU. In contrast, representatives from politics and industry underline t...
Population Genetics, Molecular Evolution, and the Neutral Theory
One of this century's leading evolutionary biologists, Motoo Kimura revolutionized the field with his random drift theory of molecular evolution—the neutral theory—and his groundbreaking theoretical work in population genetics. This volume collects 57 of Kimura's most important papers and covers forty years of his diverse and original contributions to our understanding of how genetic variation affects evolutionary change. Kimura's neutral theory, first presented in 1968, challenged the notion that natural selection was the sole directive force in evolution. Arguing that mutations and random drift account for variations at the level of DNA and amino acids, Kimura advanced a theory of evol...
J. B. Sancho
Sacerdote franciscano mallorquín compositor. Sabemos que nació en Artà pero hay discrepancia en la fechas 1772 o en 1776 y que murió en California en 1830, que ingresó en la orden en 1791 y ejerció como maestro de coro en el Convent de Sant Francesc de Palma de Mallorca. Llegó a México en 1803 pasando luego en 1804 a California donde permaneció hasta su muerte en 1830.
