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The intestinal microbiome is especially important during the first thousand days of life. Exposure to microbes in utero significantly impacts fetal development, in part through epigenetic processes and in part through hormonal influences which cause a change in the mother's intestinal microbiome. The nature of delivery and perinatal antibiotic treatment, as well as diet (especially in the postpartum period), can also influence initial microbial colonization and the development of appropriate intestinal defense mechanisms. These, in turn, can affect the expression of allergy, autoimmune disease, and brain function, among other things, later in life. The first part of this publication focuses on the development of the human microbiome in utero and the importance of normal colonization of the newborn gut in immune development and disease prevention. The second section deals with the normal development of gut microbiota and with clinical conditions associated with dysbiosis. The final chapters cover various aspects of human milk evolution and oligosaccharides.
El suicidio es considerado uno de los mayores problemas de salud pública de la sociedad moderna, tanto de atención social y sanitaria como educativa, que requiere de una mirada integral y de estrategias de actuación esenciales para su prevención, detección precoz, intervención y posvención. Este libro, lejos de ser un manual sobre la muerte, es un conjunto de reflexiones y aportaciones desde la experiencia y una mirada a la vida con rigor, profesionalidad y humanidad. En él se dota de contenido, educación y visibilidad a lo que se ha mantenido oculto, silenciado y estigmatizado hasta la actualidad: el suicidio y la autolesión. A lo largo de los capítulos se aborda la necesaria pre...
This book is the first to provide balanced examination of both pediatric liver disease and liver transplantation – two topics that are inherently related, given that most chronic liver disorders eventually require organ replacement. The different forms of liver disease encountered in the pediatric age group are first discussed in a series of disease-specific chapters that have a reader-friendly, uniform structure covering pathophysiology, diagnostic and treatment algorithms, clinical cases, and transition to adult care. Key topics in the field of liver transplantation are then addressed. Examples include indications and contraindications, surgical techniques and complications, immunosuppre...
Este libro presenta diferentes temas de vanguardia en la utilización de los probióticos, mostrando la más reciente evidencia científica, siempre conscientes de la rapidez con la que observamos cambios de paradigmas en la medicina. Los microorganismos intestinales despliegan funciones importantes y específicas para la homeostasis del anfitrión. La colonización microbiana puede no ser esencial para la vida, pero es fundamental para la nutrición, el crecimiento corporal, la inducción y la regulación de la inmunidad, la homeostasis endocrina, la maduración del sistema nervioso central e, incluso, el comportamiento. Este libro presenta una excelente descripción y puesta al día de nue...
This work examines California's history from 1520 to 1890. It also contains a ethnology of the state's population, economics, and politics.
It is possible to eliminate death and serious injury from Canada’s roads. In other jurisdictions, the European Union, centres in the United States, and at least one automotive company aim to achieve comparable results as early as 2020. In Canada, though, citizens must turn their thinking on its head and make road safety a national priority. Since the motor vehicle first went into mass production, the driver has taken most of the blame for its failures. In a world where each person’s safety is dependent on a system in which millions of drivers must drive perfectly over billions of hours behind the wheel, failure on a massive scale has been the result. When we neglect the central role of t...