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Mammalian Alkaline Phosphatases
A review and discussion of new knowledge on the structure and function of mammalian alkaline phosphatases (APs) gained over the last 25 years. It covers: * The structure, regulation and expression of the AP genes * The three-dimensional structure of APs and mutagenesis work that further defined the structural/functional domains of the isozymes * The phenotypic abnormalities of the different AP knockout mice * Our current understanding of the in vivo role of the AP isozymes. The book also describes the possible use of APs as therapeutic agents and therapeutic targets and the many uses of these enzymes in clinical medicine and in biotechnology.
Gene Families: Studies Of Dna, Rna, Enzymes & Proteins
This archival volume is an invaluable collection of rigorously reviewed articles by experts in the fields of gene families, DNA, RNA and proteins, to commemorate the passing of a giant of science — Professor Clement L Markert (1917-1999).In 1959, Clement Markert and Freddy Moller developed the concept of the isozyme, which paved the way for extensive studies of enzyme, protein and gene multiplicity across all living organisms. This important scientific discovery has had a profound influence on the biological sciences for more than 40 years, and has provided the basis for regular international meetings to discuss the biological and biomedical implications of enzyme multiplicity. More recently, this concept has been extended to a wide range of gene families of DNA, RNA, proteins and enzymes.
Mineralizing Vesicles
Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease presents the state-of-the art in the properties of mineralizing EVs and their potential clinical applications. The first chapter presents foundational biochemical and biological aspects of EVs. Next, the title coves the role of EVs in bone ossification and in cardiovascular and cartilage-related diseases. Considering the unique ability of this class of EVs to form apatite minerals assigned to their special biochemical machinery, three chapters of the book then focus on the enzymes catalysing the inorganic phosphate and calcium turn-over and the dynamic properties of the vesicles' perip...
Rethinking the History of Democracy in Spain
Focusing on the processes of political socialisation and democratisation that took place in Spain during the nineteenth and twentieth centuries, this book brings together specialists who propose the need to rethink the contemporary history of democracy in Spain to build a new narrative. To do so, the authors go down to the local level, where they are able to trace a political culture that forged the foundations of a process of political "modernization" much more complex than what conventional historiography has conveyed, even though it was not always transferred institutionally to the national level. The idea of a rural Spain that was backward, apolitical, violent and unprepared for democrac...
Cellular and Molecular Regulation of Testicular Cells
Conceptual advances in the biological sciences are marked by the applica tion of new techniques and experimental strategies. Nowhere has this ge neric principle been more apparent than in the study of testicular cells, as judged by the evolution of themes presented at the Testis Workshop over the past 23 years. Like its predecessors, the 1995 Testis Workshop was structured to offer fresh insights and approaches for understanding the mechanisms of spermatogenesis and steroidogenesis. The chapters pre sented in this book emphasize three aspects of testicular cell function: first, the molecular analysis of the cell cycle; second, examination of the cell cycle, including the function and identif...
Fusion Protein Technologies for Biopharmaceuticals
The state of the art in biopharmaceutical FUSION PROTEIN DESIGN Fusion proteins belong to the most lucrative biotech drugs—with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents a milestone of modern therapies just as Humulin®, the first therapeutic recombinant protein for human use, approved by the FDA in 1982 and Orthoclone® the first monoclonal antibody reaching the market in 1986. These first generation molecules were soon followed by a plethora of recombinant copies of natural human proteins, and in 1998, the first de novo designed fusion protein was launched. Fusion Protein Technologies for Biopharmaceuticals examines the state of the art in developing...
Genetically Modified Organisms
This book showcases the most recent advancements in genomics and biotechnology and the ongoing challenges and prospects in creating genetically modified organisms (GMOs). Readers will be acquainted with cutting-edge progress and patterns in gene and genome editing technologies and their diverse applications in medicine, biotechnology, and industry across various organisms. Furthermore, the text delves into the safety considerations and potential uses of GMOs and the regulatory frameworks in different countries. It also presents case studies illustrating how GMOs have catalyzed advancements in medicine, agriculture, and industry. This book consolidates recent discoveries and addresses the informational needs of students and researchers in the field.
Cadiz, the City: Historic and artistic highlights. Hidden gems. Local experiences.
New! 2023 update. Called the "oldest city in Western Europe", Cádiz, in Andalusia, Spain, has a rich history from the Phoenicians that founded it to the present day. This guide-history book will take you on a tour through the city and the history of the place that was once considered the centre of Spain's empire. The book includes restaurant and shopping recommendations, detailed information on the history of the city, its food and beaches and lots more. Special care is paid to the art and culture of this ancient, interesting city. If you are contemplating coming to Cádiz or are already here and want to know more beyond the bars and popular hangouts, this guide is for you.
