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Abstract: Rhabdomyosarcomas (RMS) are the most common pediatric soft tissue sarcomas. High-risk and metastatic disease continues to be associated with very poor prognosis. RMS model systems that faithfully recapitulate the human disease and provide rapid, cost-efficient estimates of antitumor efficacy of candidate drugs are needed to facilitate drug development and personalized medicine approaches. Here, we present a new zebrafish-based xenotransplant model allowing for rapid and easily accessible drug screening using low numbers of viable tumor cells and relatively small amounts of water-soluble chemicals. Under optimized temperature conditions, embryonal RMS xenografts were established in ...
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Hand painted story sequence in comic format entitled The invisible Planet.
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An emotional and at times tragic conclusion to the Liberty Sands Trilogy, It's Never Too Late To Say... uncovers terrible family secrets that have long been buried. Holly Wilson has it all: a beautiful baby daughter, a son embarking on a new career, a new job in TV and an adoring boyfriend, Philippe, but her world is about to turn upside down
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Two diaries (1813, 1818-1821) written by Julia Churchill of Newington, Connecticut. Julia was considered very pious by her family. She taught Sunday School in Newington. Often she wrote about whether or not she attended church, and what she learned. Poor health was her primary reason for not attending.