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Mitochondrial DNA, Mitochondria, Disease and Stem Cells
This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used t...
Sperm Chromatin
Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm...
Spirituality in John's Gospel
The Fourth Gospel has been known as the “spiritual gospel” since the second century, but only recently have biblical scholars attempted to express the unique spirituality found in that sacred text. Surprisingly, no consensus has emerged even after a century of research. Thus, while John’s Gospel is widely admired as a vibrant source of Christian piety, the distinct features of its spirituality remain unclear. Fr. Fiore addresses this problem from the fresh perspective of spiritual theology. Capitalizing on a century of Johannine biblical scholarship, he uses the interdisciplinary methods of spiritual theology to bring new data to the study of the Gospel and solutions to many lingering ...
