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Lena Daumanns's thesis describes structural and functional studies of the enzyme Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. It also examines the properties of small mimics of this enzyme and related binuclear metallohydrolases such as the metallo-ß-lactamases to enhance our understanding of hydrolytic cleavage of important substrates like phosphoesters and β-lactams. Overall, this project has led to a better understanding of the metal ion binding and active site structural features of the enzyme GpdQ. Daumann describes how she successfully immobilized phosphoesterase and related biomimetics on solid supports for potential applications in the area of bioremediation of organophosphate pesticides. Analysis shows that both the enzyme and biomimetics can be stored on the solid support without loss of activity. Furthermore, the author specroscopically and mechanistically characterized a number of Zn(II), Cd(II) and Co(II) complexes, some of which are among the most active biomimetics towards organophosphates reported to date. This thesis makes excellent reading for non-specialists because each chapter includes a short introduction section.
The intention of this book is to give an overview of Alfred Adler's fundamental ideas tracing the development of his theory of psychotherapy during the years between 1912 and 1937: the compensation of inferiority feeling and the founding of the concept of community feeling in emotional experience, in body and mind and in the philosophy of life. Adler doesn't adopt an objectifying external perspective; he doesn't see the overall context from outside from a reflective distance, but rather looks from his experience of human society onto the contingency of human life. All of his theoretical concepts are bound up in this holistic approach. Adler's theoretic development shows that the basic concep...
Drs. Paul L. Kaufman, Albert Alm, Leonard A Levin, Siv F. E. Nilsson, James Ver Hoeve, and Samuel Wu present the 11th Edition of the classic text Adler's Physiology of the Eye, updated to enhance your understanding of ocular function. This full-color, user-friendly edition captures the latest molecular, genetic, and biochemical discoveries and offers you unparalleled knowledge and insight into the physiology of the eye and its structures. A new organization by function, rather than anatomy, helps you make a stronger connection between physiological principles and clinical practice; and more than 1,000 great new full-color illustrations help clarify complex concepts. You can also access the c...
The first biography of a legendary tenor.
Over the last few decades, there have been dramatic improvements in the understanding and research of environmental design. Numerous methods have been developed to enhance architectural design in order for it to be more energy efficient, sustainable and health enhancing. This book presents several theories and techniques that can be used to improve how buildings are engineered and designed in order to utilize more sustainable construction methods while promoting the health of the building's occupants. Contributions to the study of environmental design have come from a diversity of fields including applied mathematics, optimization, computer science, medical research, psychology, management s...
"What do soldiers do presents a devastating new perspective on the Greatest Generation and the liberation of France, one in which the US military used the lure of easy, sexually available French women to sell soldiers on the invasion, thus unleashing a 'tsunami of male lust' among the war-weary GIs. The resulting chaos-ranging from flagrant public sex with prostitutes to outright rape and rampant venereal disease-horrified the battered and demoralized French population and caused serious friction between the two nations at a crucial point as the war drew to a close."--Page 4 of cover.