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This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. - Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France - 14 brand new chapters dedicated to coverage...
This surgical atlas illustrates the various successful thyroid surgery techniques of world-renowned surgeons. Some approaches presented include total thyroidectomy, right thyroid lobectomy, left thyroid lobectomy, minimally invasive approach to thyroidectomy, video-assisted approach to thyroidectomy, and endoscopic approaches, such as the transaxillary approach, bilateral axillo-breast approach (BABA), and trans-oral thyroid surgery (TOEVA). The Atlas is intended for a broader audience than publications for other procedures since thyroidectomy is among the most common neck procedures. The Atlas of Thyroid Surgery will help all surgeons caring for patients with thyroid disease minimize complications and perform successful thyroidectomy.
This book follows on previous works addressing sustainable development research in the Asia-Pacific region. It mainly focuses on India, a country currently facing immense challenges in the form of climate change, rapid urbanisation, and population pressures in its journey to help achieve the Sustainable Development Goals. Expecting to surpass China in terms of population in the near future, India needs to develop its own solutions in order to uphold its commitments under the Paris Agreement. This book makes a contribution in that direction by presenting case studies on various aspects of the built environment, from education to managing cities, procurement, and considerations for a circular economy. The papers gathered here offer a vital resource for government policymakers, educators, and current and future professionals, equipping them with the knowledge and expertise they need in order to overcome today’s complex challenges in the built environment.
"I learned who I was ... at Kamehameha." In 1944, J. Arthur Rath, a part-Hawaiian boy from a broken home, entered the Kamehameha School for Boys as an eighth-grade boarder. Thus began Rath's love affair with an institution that he credits with turning his life around, with giving him and other disadvantaged children of native ancestry--Hawai‘i's "lost generations"--the confidence and support necessary to make something of themselves. This is the story of that love affair. It is also the story of Rath's recent battle, together with other alumni, for the integrity of his beloved Kamehameha against the school's trustees and their organization, the powerful Bishop Estate. In a lively talk-stor...
This comprehensive, up-to-date volume defines the issues and offers potential solutions to the challenges of antimicrobial resistance. The chapter authors are leading international experts on antimicrobial resistance among a variety of bacteria, viruses including HIV and herpes, parasites and fungi. The chapters explore the molecular mechanisms of drug resistance, the immunology and epidemiology of resistance strains, clinical implications and implications on research and lack thereof, and prevention and future directions.
This book provides a comprehensive, state-of-the art review of hematopoietic stem cell transplantation (HSCT) for sickle cell disease (SCD). The book reviews new data about risk prediction for severe SCD, outlines the unique challenges of HSCT for patients with SCD, profiles the supportive care guidelines for patients who are undergoing HSCT, highlights our current understanding of the best transfusion support for SCD patients prior to, during and after HSCT, and provides new perspectives about the ethics of HSCT for pediatric patients with SCD. Published in the last few years, several landmark phase III trials that utilize matched unrelated and haploidentical donors for HSCT in SCD patients are also placed in context with respect to current management. Written by experts in the field, Sickle Cell Disease and Hematopoietic Stem Cell Transplantation is a valuable resource for physicians and researchers dealing with and interested in this challenging, yet exciting, curative therapy for sickle cell disease, that will help guide patient management and stimulate investigative efforts.
Antimicrobial resistance (AMR) is a global public health threat that needs immediate attention and action from the scientific community. This book compiles and presents the latest and most important aspects of AMR, including the biology involved, its persistence and spread, and novel approaches to tackle this threat. The book first describes the mechanisms and spread of AMR, and then discusses the various approaches and strategies for combating it. Important topics include, microbial pathogenesis, AMR traits and major mechanisms underlying drug-resistance and the emerging strategies and technologies for combating AMR. Emphasis has been given on current developments about natural products inc...
Part of the popular Orthopaedic Knowledge Update® series, this comprehensive orthopaedic resource covers all aspects of the latest innovations in tumor care and optimized treatment in a single, convenient volume. Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by Geoffrey W. Siegel, MD, FAAOS, and J. Sybil Biermann, MD, FAAOS, Orthopaedic Knowledge Update®: Musculoskeletal Tumors 5 reflects cutting-edge research and understanding of the molecular basis of neoplastic disease and optimized treatment options since the last volume published in 2020. Written and edited by leading orthopaedic surgeons and specialists, OKU®: Musculoskeletal Tumors 5 provides deep insight, real-world patient scenarios, and best practices supported by the latest evidence.