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Sickle Cell Disease and Hematopoietic Stem Cell Transplantation
This book provides a comprehensive, state-of-the art review of hematopoietic stem cell transplantation (HSCT) for sickle cell disease (SCD). The book reviews new data about risk prediction for severe SCD, outlines the unique challenges of HSCT for patients with SCD, profiles the supportive care guidelines for patients who are undergoing HSCT, highlights our current understanding of the best transfusion support for SCD patients prior to, during and after HSCT, and provides new perspectives about the ethics of HSCT for pediatric patients with SCD. Published in the last few years, several landmark phase III trials that utilize matched unrelated and haploidentical donors for HSCT in SCD patients are also placed in context with respect to current management. Written by experts in the field, Sickle Cell Disease and Hematopoietic Stem Cell Transplantation is a valuable resource for physicians and researchers dealing with and interested in this challenging, yet exciting, curative therapy for sickle cell disease, that will help guide patient management and stimulate investigative efforts.
Venturing in Faith
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Interdisciplinary Pediatric Palliative Care
"We hope that the lives of all children will be filled with possibility, with open horizons and rainbows into the future. Children with serious illnesses, their families, and those who care for them, confront the realization that "not everything is possible," that despite dramatic scientific and medical advances, the lifespan of some children will be shortened. This threat of premature loss heightens the sense of time for children and families alike, and challenges clinicians to create new pathways of hope for them"--
Pediatric Psycho-oncology
Pediatric Psycho-Oncology is a comprehensive handbook that provides best practice models for the management of psychological, cognitive, and social outcomes of adolescents living with cancer and their families. Chapters cover a wide range of topics including psychological aspects of particular pediatric cancers and their treatments, how to talk to a child and family at critical times during the disease course, genetic testing, individual, family, educational, psychological and psychiatric interventions, and caring for international patients . Each chapter highlights the necessity of embracing an interdisciplinary approach to ensure that each child has the best options for living with cancer ...
Gene and Cell Therapies for Beta-Globinopathies
Hemoglobin defects, specifically sickle cell disease & thalassemia, combined, constitute the most common monogenic disorders in the world. In fact, nearly 2% of the world’s population carries a globin gene mutation. The transfer of the corrective globin gene through the HSC compartment by allogeneic HSC transplantation (HSCT) has already proven curative in both SCD and thalassemia patients, and provides the proof of concept that genetic manipulation of the defective organ might be equally therapeutic. However, procedural toxicities and the requirement of an HLA-matched sibling donor limit this approach to a fraction of affected individuals. The editors review the progress & the state of th...
Abraham
Everyone knows that Abraham is one of the most important characters in the Bible but why should a man who lived nearly 4,000 years ago still matter to Christians today? Join with Meg and meet Abraham as you've never met him before. Heralded as an exemplar of faith, here is a man with his own distractions and doubts, whose human failings are only too evident. Read a story of journeying, of challenges, of false turns and unbelievable promises, and experience their relevance to your own faith and the world we live in. And finally, encounter a God whose love and faithfulness covers all our disbelief, our mistakes and our own faithlessness, and whose promises always come to fulfilment.
Bone Marrow Transplantation, An Issue of Hematology/Oncology Clinics of North America
This issue of Hematology/Oncology Clinics of North America, guest edited by Drs. Bipin Savani and Mohamad Mohty, is devoted to Bone Marrow Transplantation. Articles in this issue include: Acute Myeloid Leukemia (AML); Acute Lymphoid Leukemia (ALL); Myelodysplastic Syndrome (AML); Myeloproliferative disorders (MPD); Chronic Lymphoid Leukemia; Chronic Myeloid Leukemia (CML); Multiple Myeloma and Amyloidosis; Non-Hodgkin Lymphoma (NHL); Hodgkin Lymphoma (HL); Severe Aplastic Anemia (SAA) and Paroxysmal Nocturnal Hemoglobinuria (PNH); Sickle Cell Anemia; Thalassemia; Benign immunodeficiency diseases; and Referral to transplant centers.
Abraham
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