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Dr. Paul Giacomin is a co-founder of Paragen Bio. Dr. Siracusa is the founder and president of Nemagen Discoveries. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past d...
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Published in August of 2008, WAIS–IV is the most widely used intelligence test for adults in the world. Substantive changes were made to the WAIS-IV from the WAIS-III leaving clinicians with questions as to how to use and interpret the measure effectively. Written by the creators of the new test, this book serves as the ultimate insider's guide to the new test, providing users with the kind of access to norms and data that would be unavailable to any subsequent book on clinical use of this measure. The book discusses the changes made between 3rd and 4th editions along with an FAQ and answers about use and interpretation. The reader is instructed how to interpret composite scores, and every...
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Badjelly The Witch can turn children into sausages or chop them up to make boy-girl soup. She can turn policemen into apple trees or bananas into mice and she is the wickedest witch in all the world. Searching for Lucy, their cow, Tim and Rose become lost in the great black forest. There they meet Binklebonk the Tree Goblin, Mudwiggle the worm, Silly Sausage the grasshopper and Dinglemouse. When they are captured by Badjelly, it is Dinglemouse who saves them by escaping and fetching his friend Jim the Giant Eagle. A charming fairy tale which has delighted children for many years, this edition is copiously illustrated with Spike Milligan's own drawings which have been specially adapted and beautifully hand coloured.