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Ein (ent)spannendes Märchen 14. April 2010: Der isländische Vulkan Eyjafjallajoekull bricht aus. Über 2000 Kilometer entfernt wachen Lena und Merlin in ihren Betten auf und reiben sich verschlafen die Augen. Keiner von ihnen hat nur die leiseste Ahnung, dass der Vulkanausbruch ihr gewöhnliches Leben grundlegend verändern wird. Denn die Aschewolke macht etwas sichtbar, das für das menschliche Auge unsichtbar bleiben sollte. Merlin entdeckt es als erster. Als er Lena einweiht, beginnt für die beiden ein (ent)spannendes Abenteuer, von dem andere Schüler nur träumen können … Und du? Wie sieht es mit deinen Abenteuern aus? Warst du schon einmal in einem Zauberladen? Nicht in einem, in...
Aatami Rymättylä hat den Weg aus der drohenden Ölkrise gefunden: einen winzigen Akku, der Strom im Überfluss liefern kann. Um die umwälzende Erfindung zu vermarkten, fehlt Aatami jedoch das Geld. Zum Glück nimmt sich Eeva Kontupohja des vom Pech verfolgten Weltretters an. Die neue Energiequelle stösst jedoch nicht nur auf Gegenliebe. Die Ölmultis setzen einen sizilianischen Killer auf Aatami an.
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This book describes in 13 chapters mechanisms of P450 used to monooxygenate substrates via the NAD(P)H/O2 pathway using its peroxidase and peroxygenase functions. P450 also utilizes peroxides, peracids, periodate and iodosobenzene to oxygenate substrates via the shunt pathway. Also described are mechanisms used in the oxidation of pharmaceuticals by CYP3A4; acyl- carbon cleavage by CYP17A1, CYP19A1 and CYP51A1; metabolism of tetrabromodiphenyl ethers and bile acids by CYP2B6 and CYP3A4; metabolism of ω-6 and ω-3 polyunsaturated fatty acids; H2O2-mediated peroxygenation of substrates using substrate misrecognition; P450 oxidative reactions using electrochemical methods; electron transfer to P450 by redox proteins; hydroxylation of 1,8-cineole by P450cin; and peroxygenation by unspecific peroxygenases using H2O2. The topics covered are relevant to P450 researchers, professors and students from a variety of disciplines ranging from pharmacology, toxicology and microbiology to chemistry.
Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.
The US has embarked on a military adventure, "a long war", which threatens the future of humanity. US-NATO weapons of mass destruction are portrayed as instruments of peace. Mini-nukes are said to be "harmless to the surrounding civilian population". Pre-emptive nuclear war is portrayed as a "humanitarian undertaking". While one can conceptualise the loss of life and destruction resulting from present-day wars including Iraq and Afghanistan, it is impossible to fully comprehend the devastation which might result from a Third World War, using "new technologies" and advanced weapons, until it occurs and becomes a reality. The international community has endorsed nuclear war in the name of worl...