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Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450
This book describes in 13 chapters mechanisms of P450 used to monooxygenate substrates via the NAD(P)H/O2 pathway using its peroxidase and peroxygenase functions. P450 also utilizes peroxides, peracids, periodate and iodosobenzene to oxygenate substrates via the shunt pathway. Also described are mechanisms used in the oxidation of pharmaceuticals by CYP3A4; acyl- carbon cleavage by CYP17A1, CYP19A1 and CYP51A1; metabolism of tetrabromodiphenyl ethers and bile acids by CYP2B6 and CYP3A4; metabolism of ω-6 and ω-3 polyunsaturated fatty acids; H2O2-mediated peroxygenation of substrates using substrate misrecognition; P450 oxidative reactions using electrochemical methods; electron transfer to P450 by redox proteins; hydroxylation of 1,8-cineole by P450cin; and peroxygenation by unspecific peroxygenases using H2O2. The topics covered are relevant to P450 researchers, professors and students from a variety of disciplines ranging from pharmacology, toxicology and microbiology to chemistry.
Preclinical Development Handbook
A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screen...
PCBs
In April 2000 researchers from around the world met in Lexington, Kentucky to bring together the very latest information on the chemistry and biological effects of the environmental pollutants known as Polychlorinated Biphenyls (PCBs). The result is a comprehensive and extensive treatment of the very latest findings on all significant subjects relating to PCBs and their health risks. The thorough introduction and sixty-two scientific papers presented here represent the most up-to-date research by scientists in government, private industry, and academia.
La Bandiera
E-Book di 81 pagine. Un racconto lungo che si svolge all’inizio del 900 sulle Alpi, al confine tra Francia e Italia. Un racconto che parla di Alpini, di onore e dell’amore per la patria. Concetti che oggi a tanti possono sembrare assurdi, ma che a quell’epoca erano molto sentiti. Ma nel racconto vi è molto di più. L’autore, che pure mostra simpatia per i concetti di cui abbiamo appena parlato, ci fa capire come se questi concetti non esistessero sarebbe molto meglio. Il mondo non avrebbe più guerre, non vi sarebbero rivalità tra nazioni, non esisterebbero i confini. Ed ad esprimere questi concetti più grandi ancora dell’onore e dell’amore di patria è un demente, un povero ragazzo che vive felice vagabondando tra l’Italia e la Francia, ignaro che trattasi di due nazioni diverse. Infine, vi è la figura di un disertore, un anima inquieta per cui l’esercito rappresenta la sola possibilità di uccidere il prossimo in piena legalità. Prima del racconto viene data una visione di insieme di come gli argomenti Alpi, Alpini, Alpinismo, Club Alpino Italiano erano visti all’inizio del 1900. Il tutto è corredato da ampia iconografia.
Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer
Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer, the latest volume in the Advances in Pharmacology series, presents not only the function of cytochrome P450 but also its pharmacological roles in inflammation and cancer. - Contains contributions from the best authors in the field - Ideal reference for those conducting research in cancer, inflammation, cytochrome P450, metabolism, liver disease, and oxidative stress - Provides an essential resource for pharmacologists, immunologists, and biochemists
Annual Report
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