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Advances in cellular physiology and molecular biology have now disclosed the metabolic changes and adaptational responses of the heart to various kinds of stresses. Topics covered in this volume include the regulation of myocardial proteins in mechanical overload, the alteration of adrenoceptors in the stressed heart, metabolic adaptation in cardiac hypertrophy, intracellular calcium metabolism in the ischemia-reperfused myocardium, calcium overload as a cause of myocardial stunning, acquisition of ischemic tolerance by ischemic preconditioning, factors that accelerate myocardial injury, and ventricular remodeling in the ischemic heart. As an update of the latest findings in basic cardiology, this book will benefit both researchers and clinical practitioners.
The immense growth in the number of articles on adenosine cardioprotection in recent years has been related in large part to the hypothesis that adenosine plays a role in ischemic preconditioning. Ischemic preconditioning is the phenomenon in which a brief period of ischemia (and reperfusion) prior to a more prolonged occlusion reduces myocardial infarct size. This form of myocardial protection has received much interest because ischemic preconditioning has been shown to be the most potent means of reducing infarct size in all animal models so far tested. Within the last six years, the principal focus of adenosine cardioprotection research has centered on the role of adenosine receptors. It ...
This book contains a selection of lectures given during the 5th International Symposium on Adenosine and Adenine Nucleotides, recently held in Philadelphia, Pennsylvania. Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology covers a wide range of subjects from molecular and cellular biology to clinical applications. A great emphasis has been placed on cutting edge information derived from studies using molecular and cellular biology techniques applied to the field of adenosine and adenine nucleotide research. The book also includes information on potentially promising developments in the therapeutic applications of adenosine related drugs and ATP. The tradition of past meetings is also maintained by including in the program presentations of new research in the areas of purine metabolism and physiology, and pharmacology of adenosine and adenine nucleotides. Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology is an excellent, up-to-date reference book for basic and clinical scientists in the field of adenosine and adenine nucleotides.
A critical review of the most up-to-date research on purines and myocardial protection. The role of purines in reversible `myocardial stunning' and irreversible (myocardial infarction) ischemic injury, ventricular arrhythmias, and ischemic preconditioning is discussed in detail, by experts. All reviews address recent and rather controversial issues on purines and myocardial protection. Mechanisms of cardioprotection of exogenous versus endogenous purines are discussed in detail. The contribution of internationally recognized experts in the field of purines and cardiovascular physiology and in myocardial protection makes this a unique and interesting book for clinicians, basic scientists and students.
Numerous studies have documented the importance of diastolic dysfunction in heart disease. Now, providing cardiologists with the most current information available on the subject, the editors have pulled together contributions from an impressive array of top researchers and compiled them into one comprehensive, carefully edited source, Diastolic Relaxation of the Heart, Second Edition: The Biology of Diastole in Health and Disease. This brand new Second Edition, based on a recent meeting, includes such topics as: molecular biology of relaxation; consequences of altered gene expression; impaired relaxation in experimental models (ischemia and hypoxia, and hypertrophy and failure); diastolic dysfunction in the diseased human heart. Diastolic Relaxation of the Heart, Second Edition: The Biology of Diastole in Health and Disease, the successor to the editors' bestselling work on the same subject, published in 1987 - belongs on the shelf of every practising cardiologist. It will also be an invaluable addition to the library of scientists researching the effects of diastole on heart function.
Ventricular assist device has become one of the standard therapies for the support and the management of the failing heart. Updating our knowledge about these devices is mandatory in order to improve patient outcomes. In this book we can read the efforts made by many physicians concerned with the treatment of heart failure with mechanical devices. We all hope that the information compiled by experts in ventricle assist devices in this book will help us all to do better our main task - heal patients.
Vols. for 1898-1941, 1948-56 include the Society's proceedings (primarily abstracts of papers presented at the 10th-53rd annual meetings, and the 1948-56 fall meetings)
Uber die Analyse des spirituellen Diskurses als einem erstmals in dieser Bandbreite gesichteten Phanomen wird ein Psychogramm der japanischen Gegenwartsgesellschaft und ihrer kulturschaffenden Vertreter erstellt. Der Einblick in die Debatten sowie in die Mechanismen der Identitatsindustrie dient dazu, ein differenziertes, zeitgemasses Japanbild zu gewinnen. Vielejapanische Literaten und Denker, Kritiker und Kunstler widmen sich heute der Suche nach indigener Identitat. Diese wird haufig uber eine japanische Spiritualitat definiert. Wahrend sich die Studie den ethno-romantischen, oft einem nostalgischen Nationalismus verpflichteten Selbstfindungs- undSelbstbehauptungsdiskursen der intellektuellen Szene Japans im allgemeinen widmet, berucksichtigt sie anhand von Erorterungen zeitgenossischer Texte bekannter und weniger bekannter Autoren ebenso die literarische Behandlung des Themas Religion.Lisette Gebhardt ist Privatdozentin fur moderne japanische Literatur. Ihre Forschungsschwerpunkte sind Literatur und ihr Bezug zur Religion; New Age in Japan; japanische Ideengeschichte; Intellektuelle, Kulturszene und Lifestyleim gegenwartigen Japan.
No. 2, pt. 2 of November issue each year from v. 19-47; 1963-70 and v. 55- 1972- contain the Abstracts of papers presented at the annual meeting of the American Society for Cell Biology, 3d-10th; 1963-70 and 12th- 1972- .