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Schwann Cell Development and Pathology
This book presents recent topics on the development, differentiation, and myelination of Schwann cells, as well as pathological mechanisms and therapeutic approaches for peripheral neuropathies, such as Charcot–Marie–Tooth diseases, amyloid polyneuropathy, immune-mediated neuropathy and diabetic neuropathy. The rapid progress of molecular biological techniques in the last decades, especially for RNA techniques and gene modification technologies have allowed us to investigate the pathobiology of Schwann cells in vivo and in vitro. Studies combining recent stem cell biology with recent biotechnology, which is now closely linked to physicochemical fields, further explain how Schwann cell li...
Neurobiology of the Axon in Health and Disease
Ever since Santiago Ramón y Cajal sketched his captivating panels of the microscopic structure of the brain with its vast diversity of neuronal morphology over a century ago, scientists have been drawn to this seemingly chaotic network of neurites and processes to uncover how structure relates to function. During the course of a century, we have moved from merely describing neuronal and glial morphology to furthering our understanding of such intricate processes as organelle and factor transport, cellular compartmentalization, neuronal polarity, cytoskeleton dynamics, neurite pathfinding, and the impact of pathophysiological insult on these structures and events. Yet to this day, and likely...
Neuroglia
Neuroglia is now published as part of Brain Sciences with a new section Editor-in-Chief Prof. Sergey Kasparov.
Cellular and Molecular Biology of Filamentous Fungi
An ideal starting point for any research study of filamentous fungi. • Incorporates the latest findings from such disciplines as physiology, taxonomy, genomics, molecular biology and cell biology. • Begins with an historical perspective, cell morphology and taxonomy, and moves on to such topics as cell growth, development, metabolism, and pathogenesis. • Presents the full range of the fungal kingdom and covers important topics as saprophytes, pathogens and endophytes. • Serves as a recommended text for graduate and undergraduate students.
Postvelar Harmony
This book examines the formal bases of postvelar harmony and its crosslinguistic variation. It is of interest especially to phonologists concerned with segmental harmony and its explanation within Optimality Theory. Postvelar harmony in two unrelated languages, Palestinian Arabic and St'át'imcets Salish, is examined in detail. The result is the first comprehensive clarification of postvelar phonology for either language. Two harmonies are distinguished: uvularisation harmony ('emphasis spread') and pharyngealisation (tongue-root-retraction) harmony. The distinction between these two in the Arabic and the Salish is supported by much instrumental phonetics data. The complex harmony properties are explained as the result of systematic interaction between Correspondence, Alignment and Grounded constraints. In the course of the investigation, the segmental inventories of both languages are clarified, and a careful understanding of the distinction between phonology and phonetics, and the use of phonetics in phonology, is applied.
The Oxford Handbook of Vowel Harmony
This handbook provides a detailed account of the phenomenon of vowel harmony, a pattern according to which all vowels within a word must agree for some phonological property or properties. Vowel harmony has been central in the development of phonological theories thanks to its cluster of remarkable properties, notably its typically 'unbounded' character and its non-locality, and because it forms part of the phonology of most world languages. The five parts of this volume cover all aspects of vowel harmony from a range of theoretical and methodological perspectives. Part I outlines the types of vowel harmony and some unusual cases, before Part II explores structural issues such as vowel inven...
Optimality Theory and Language Change
This work discusses many optimization and linguistic issues in great detail. It treats the history of a variety of languages, including English, French, Germanic, Galician/ Portuguese, Latin, Russian, and Spanish and shows that the application of Optimality Theory allows for innovative and improved analyses. It contains a complete bibliography on OT and language change. It is of interest to historical linguists, researchers into OT and linguistic theory, and phonologists and syntacticians with an interest in historical change.
Human iPS Cells in Disease Modelling
Human iPS cells have a great potential to be cell sources for regenerative medicine because of the promise of infinite self-renewal and the capability to differentiate into multiple cell types. This book focuses on another great potential of human iPS cells, which is the establishment of human disease models using patient-specific iPS cells. Human iPS cells can be easily obtained from a patient’s somatic cells and provide the entire information on the patient’s genome. Accordingly, we can generate disease models for inheritable diseases in cell culture dishes using iPS cells. This is a quite new technique but holds tremendous potential for our increased understanding of pathogenesis, and will then be the basis for novel drug development industries. All the authors are leading researchers in this field and they have reported many kinds of patient-derived iPS cells. In this book, they introduce the aspects that could be recapitulated in terms of disease modelling as well as further innovative findings such as novel pathogenetic insights and novel therapies.
Regulatory T-Cells
Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. This volume focuses on regulatory T-cells. - Contributions from leading authorities and industry experts - Informs and updates on all the latest developments in the field
Japanese Baseball
This book--the first in the English language to contain an exhaustive collection of Japanese baseball data--presents basic statistical information and listings for every Japanese professional baseball season from 1936 through 1997. The first part contains yearly breakdowns of team standings; qualifiers for batting and earned run championships; leaders in home runs, runs batted in, wins and strikeouts; all-star game results; Japan Series results; Best Nine selections; Gold Glove selections; and award winners. Sections on career records and single-season records are provided in the second part of this work. Appendices list no-hit, no-run games, Japanese Hall of Famers, and records of foreign tours of Japan by professional teams.
