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Neuroanatomy and Pathology of Sporadic Alzheimer's Disease
As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail
Neuroanatomy and Pathology of Sporadic Parkinson's Disease
The synucleinopathy sporadic Parkinson’s disease (sPD) is the second most frequent degenerative disorder of the human nervous system after Alzheimer’s disease. The propensity for developing sPD exists in all ethnic groups worldwide, and the prevalence of the disorder increases considerably with age, thereby imposing an enormous social and economic burden on societies with increased life expectancy. The sPD-associated pathological process is progressive, does not go into remission, and can take decades to reach its culmination if it is not be terminated prematurely by death owing to other causes. Against the background of the normal morphology and anatomy, the authors analyze the pathoanatomy of sPD in the nervous system at various neuropathological stages and summarize the potential functional consequences of the lesions.
Parkinson's Disease
Parkinson's disease (PD) is characterised by an insidious onset with slowing of emotional and voluntary movement, muscular rigidity, postural abnormality and tremor. Parkinson's disease was first described in 1817 by James Parkinson. It is a progressive, neurological disease mainly affecting people over the age of 50, although at least 10 per cent of cases occur at an earlier age. It affects people of either sex and all ethnic groups. In the normal brain, some nerve cells produce the chemical dopamine, which transmits signals within the brain to produce smooth movement of muscles. In Parkinson's patients, 80 percent or more of these dopamine-producing cells are damaged, dead, or otherwise degenerated. This causes the nerve cells to fire wildly, leaving patients unable to control their movements. This new book brings together the latest research in this field.
Sacra Pagina: Colossians and Ephesians
No two works in the Pauline Epistles resemble each other as closely as Colossians and Ephesians. Often recognized for their majestic tone and powerful theological statement, Colossians and Ephesians also present many challenges of interpretation. Most commentaries on these letters seem preoccupied with the same few issues, particularly the question of authorship. As MacDonald addresses these classic questions, she offers a fresh perspective on Colossians and Ephesians by making use of insights from the social sciences. Moreover, by paying attention to subtle differences between the two letters, she brings their distinct perspectives into sharp relief. MacDonald highlights the interplay betwe...
Hebrews and the Temple
In Hebrews and the Temple Philip Church argues that the silence of Hebrews concerning the temple does not mean that the author is not interested in the temple. He writes to encourage his readers to abandon their preoccupation with it and to follow Jesus to their eschatological goal. Following extensive discussions of attitudes to the temple in the literature of Second Temple Judaism, Church turns to Hebrews and argues that the temple is presented there as a symbolic foreshadowing of the eschatological dwelling of God with his people. Now that the eschatological moment has arrived with the exaltation of Christ to the right hand of God, preoccupation with the temple and its rituals must cease.
Reading the Gospel of John’s Christology as Jewish Messianism
The essays in Reading the Gospel of John’s Christology as Jewish Messianism: Royal, Prophetic, and Divine Messiahs seek to interpret John’s Jesus as part of Second Temple Jewish messianic expectations. The Fourth Gospel is rarely considered part of the world of early Judaism. While many have noted John’s Jewishness, most have not understood John’s Messiah as a Jewish messiah. The Johannine Jesus, who descends from heaven, is declared the Word made flesh, and claims oneness with the Father, is no less Jewish than other messiahs depicted in early Judaism. John’s Jesus is at home on the spectrum of early Judaism’s royal, prophetic, and divine messiahs
Parkinson's Disease
In recent years, considerable advances have been made in our knowledge and understanding of Parkinson's disease (PD). In particular, there has been an explosion of information regarding genetic contributions to the etiology of PD and an increased awareness of the importance of the non-motor features of the disease. Theories regarding the pathogenes
Parkinson's Disease
Parkinson's Disease has traditionally been seen as a movement disorder, and diagnosed by the development of tremor. However, we are beginning to understand that the disease manifests itself in many ways, and that earlier diagnosis might be possible through non-tremor symptoms. This textbook aims to tell the full story of non-motor and non-dopaminergic features of Parkinson's Disease.
The Conclusion of Luke-Acts
The conclusion of Luke-Acts is regarded as one of the most important chapters of Luke's two-volume work. Several significant Lukan themes are found in Acts 28, all of which make some contribution to the purpose and aim of the author in writing Luke-Acts: the Gentile mission, the triumph of God's Word, and the relationship of Christianity with Judaism and Rome. Acts 28 contains many historical problems that have been debated for centuries, including the we statements, the figure of Paul in Acts 28, and the abrupt-ending. Puskas compares the conclusion of Acts with other important chapters of Luke-Acts: the introduction of the Gospel, the conclusion of Acts, the defense of Paul chapters, as well as other passages. In this significant chapter of Acts 28 there are still fundamental problems of exegesis that need to be addressed: What is the literary function of Acts 28? What is Luke trying to tell his readers in the text?
