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Technology underpins everything we do, and the contracts which underpin the delivery of technology-related services are important from both an economic and social perspective. Negotiating technology-related contracts can, however, be challenging: for the uninitiated or uninformed, the significance of the points under discussion may be unclear, confusing and often at odds with the outcomes one might expect in more traditional 'bricks and mortar'-style contracts.To avoid unnecessarily protracted negotiations, it is essential to have a clear understanding of: (i) what each part of a technology-related contract is designed to deal with; (ii) what the customer and service provider seek to protect...
There is a growing trend in virtual world commercial transactions. In order to protect people’s rights in the virtual world and keep pace with innovative trading demands, it is essential for us to understand the commercial implications of virtual world economies by evaluating the effectiveness of the existing laws, practices, and policies in business, technology, intellectual property and related fields. This book, in 11 sections, investigates the issues and opportunities associated with commercial transactions in the virtual world. In 29 detailed essays, this book analyses every facet of virtual world transactions, including the nature of virtual commercial transactions, virtual goods and...
This unique book offers an in-depth, best-practices guide to diagnosis and management of mastocytosis, a too-often underdiagnosed disease. Mastocytosis: A Comprehensive Guide will open with a general overview and discussion of mast cell biology, addressing tryptase and other diagnostic markers in detail. Comprehensive diagnostic criteria and classification will follow, with special emphasis on commonly-seen related manifestations: skin disease, pediatric mastocytosis, gastrointestinal indicators, osteoporosis, anaphylaxis, venom and drug allergy, and pregnancy. Mastocytosis will be an ideal resource for not only the allergist confronted with this condition, but for a growing, multi-disciplinary audience of hematologists, gastroenterologists, dermatologists, pediatricians, primary care providers and other clinicians who encounter this disease in their patients.
Now, there's a unique resource developed specifically for senior managers and legal professionals tasked with ensuring their offshore sourcing contracts result in increased bottom lines ... not increased legal battles. The OFFSHORE BUSINESS SOURCING SPECIAL REPORT ON LAW & STRATEGY will help you navigate the many legal and strategic hurdles inherent to the offshoring process. You'll stay ahead of changing legislation, uncover effective tax structuring options, and learn strategies to overcome intellectual property challenges.
Covering the broad range of benign and malignant disorders that affect the hematopoietic system, Hematopathology, 3rd Edition, remains your #1 source of authoritative information in this fast-changing field. Edited by Dr. Elaine Jaffe and a team of globally renowned, expert co-editors, it offers a wealth of up-to-date information in an easily accessible format, equipping you to deliver more accurate and actionable pathology reports. Comprehensive in scope, this highly illustrated, practical text is a must-have resource for residents and practicing pathologists alike. - Helps you navigate the latest changes in the classification of hematolymphoid neoplasms, providing guidance for use of both ...
In this issue of Immunology & Allergy Clinics, guest editor Dr. Cem Akin brings his considerable expertise to the topic of Mast Cell Disorders. Top experts in the field provide readers with information on the identification, management, and treatment of mast cell disorders and mastocytosis. - Contains 9 relevant, practice-oriented topics including drug and venom allergy in mastocytosis; quality of life in mastocytosis; effect of gender and special considerations for women in mastocytosis and anaphylaxis; management of mediator symptoms, allergy, and anaphylaxis in mastocytosis; and more. - Provides in-depth clinical reviews on mast cell disorders, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
This issue of Immunology and Allergy Clinics, guest edited by Mariana C. Castells, MD, is devoted to Mastocytosis. Articles in this issue include: New Insight into Clonal Mast Cell Disorders Including Mastocytosis; Cutaneous Mastocytosis in Adults and Children: New Classification and Prognostic Factors; Hymenoptera Anaphylaxis as a Clonal Mast Cell Disorder; Non Clonal Mast Cell Activation Syndrome: A growing body of evidence; Familial Tryptasemia Syndromes: Genotyping and Symptoms; POTS and EDS: Entities Associated to Mast Cell Activation; KIT Mutations: New Insight and Diagnostic Value; Patients’ Perceptions in Mast Cell Activation Disorders; Mast Cell Mediators of Significance in Clinical Practice; Tyrosine Kinase Inhibition in Mast Cell Activation Disorders; Gastrointestinal Involvement in Mast Cell Activation Disorders; Bone Marrow Expression of Mast Cell Disorders; Genomics and Proteonomics in Clonal Mast Cell Disorders; and Pediatric Expression of Mast Cell Activation Disorders.
Tumors and Cancers: Endocrine Glands – Blood – Marrow – Lymph provides succinct reviews of neoplastic growths disrupting normal functions of affected structures. Each chapter presents a state of the art summary of tumor/cancer of a particular type in relation to its biology, epidemiology, disease mechanisms, clinical signs, diagnosis, treatment and prognosis.
Systemic mastocytosis (SM) is a heterogeneous group of rare hematologic neoplasms that are characterized by clonal proliferation of mast cells in the bone marrow and extracutaneous organs, which can cause symptoms due to mast-cell mediator release and end-organ damage due to mast-cell infiltration. Mastocytosis is classified as a distinct entity by the WHO because of its unique clinicopathological features. Over 95% of patients harbor the somatic KIT driver mutation D816V. This book focuses on the diagnosis of SM, with up-to-date practical guidance on the management of patients with SM, who may present to a variety of healthcare providers on their diagnostic journey. It will be invaluable to clinicians, medical students, nurses, pharmacists and scientists in understanding the clinical, diagnostic and management challenges associated with SM. Table of Contents: • Definitions and classification • Epidemiology and pathophysiology • Diagnosis • Management of non-advanced systemic mastocytosis • Management of advanced systemic mastocytosis • Future directions