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B Cell Protocols
B-lymphocyte development and function remains an exciting area of research for those interested in the physiology and pathology of the immune system in higher animals. While recent advances in genetics and cellular and molecular biology have provided a large spectrum of powerful new experimental tools in this field, it is both time consuming and often very difficult for a student or just any bench-side worker to identify a reliable experimental protocol in the ocean of the literature. The aim of B Cell Protocols is to provide a collection of diverse protocols ranging from the latest inventions and applications to some classic, but still frequently used methods in B-cell biology. The authors ...
Portrait of the Immune System
Using the published work of Nobel Laureate Niels Kaj Jerne, this book shows how he developd his ideas. The book is a compilation of his published work, but in fact it is much more than that. Whether the reader wants to read the book systematically, or only browse, it opens a fascinating world of hypotheses, theories, facts and vistas. His selection theory, his view of how immunological diversity is created, and his concept of lymphocytes interacting as a network, reveals Jerne's revolutionary spirit. The book ought to be a rich source of inspiration for everyone interested in science and how science is made.
B Cell Receptor Signaling
This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
Ahead of the Curve
A biography of one of America's most famous and important molecular biologists.
The Biology of Idiotypes
The phenomenon of idiotypy was discovered almost thirty years ago, but it was only during the past decade that it attracted widespread interest and became the subject of numerous research investigations. From the outset, much of the interest in idiotypy was based on its implications with respect to the repertoire of antibodies. Kunkel showed, for example, that idiotypes associated with certain human myeloma or Bence-Jones proteins were present in normal human globulins at levels of less than one part per million. Also, Oudin's original definition of idiotypy implied that idiotypes could be uniquely associated with individual rabbits as well as with particular antigen-binding specificities. S...
RNA Interference, Editing, and Modification
This volume presents a comprehensive collection of cuttingedge methods for elucidating the function of new genes and altering gene expression. These readily reproducible techniques can be used either in transient and stable gene splicing applied to worms, flies, trypanosomes, mammals, and plants, or in studying RNA editing mechanisms in a wide range of organisms, including systems that involve the conversion of one base to another and insertion/deletion editing. Topics of interest include stable and transient RNA interference, gene silencing, RNA editing, bioinformatics, small noncoding RNAs, and RNomics. Special attention is given to methods for the identification and characterization of small RNAs involved in RNA interference or modification. Readily reproducible protocols for discovering new genes or altering gene expression.
Novel Systems for the Study of Human Disease From Basic Research to Applications
This proceedings brings together scientific papers covering the breadth and significance of model animals used in scientific research, and scientific and policy summaries based on workshop discussions.
A Place in History
A Place in History: The Biography of John C. Kendrew is the story of the influential 20th century scientific pioneer and winner of the 1962 Nobel Prize in chemistry.
Max Delbruck And Cologne: An Early Chapter Of German Molecular Biology
The history of molecular biology in Germany is closely linked to the Institute of Genetics in Cologne, the first molecular biological Institute at a German university. Founded in 1959 by the émigré physicist and future Nobel laureate Max Delbrück, the Institute was the first in Germany to implement less hierarchical American organizational structures and research habits. The Institute had already gained an excellent international scientific reputation by the beginning of the 1960s.This volume comprises the recollections of scientists pertaining to the Institute's research, organization and other specificities. Articles by historians of science analyze the historical background and international framework of the Institute's foundations and genetic research. In addition, the scientists discuss contemporary questions of science policy with regard to teaching and the impact of the internal structures of scientific institutions on the quality of research.
The Future of Genetics
The Future of Genetics considers where research in genetics, molecular biology, and medicine is headed while trying to cleanly separate facts from fiction and ideologies. This new volume explores the last 150 years and how different strands of biological research have become interwoven to create a new kind of interdisciplinary science.
