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FEMS Microbiology Letters
An international journal providing for the rapid publication of short reports on microbiological research.
Globus
None
Au-delà de nos limites biologiques
Entre vie prolongée et mort orgasmique, l'un des plus grands généticiens de la planète nous révèle la découverte qui va bouleverser notre monde. Rêve ou cauchemar ? Depuis deux siècles, nous gagnons chaque année trois mois d'espérance de vie. Dans un avenir plus proche qu'on ne l'imagine, nous pourrons vivre cinquante, cent ans de plus. Discrètement, une équipe de chercheurs français a découvert les secrets de la longévité. Pour la première fois, celui qui la dirige nous raconte l'histoire de cette découverte qui va révolutionner l'humanité et relancer l'espoir de vaincre enfin le cancer. Miroslav Radman est l'un des papes de la biologie moléculaire, l'un des plus grand...
Stress-Induced Mutagenesis
The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes. This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.
Single-Stranded DNA Binding Proteins
The genomes of cellular organisms are organized as double-stranded DNA, a structure that must be unwound to provide DNA replication, recombination, and repair machinery access to genomic information. However, DNA unwinding comes with inherent risks to genome stability. To help mediate these risks, bacterial, archael, and eukaryotic cells have evolved protective ssDNA-binding proteins (SSBs) that bind ssDNA with high affinity and specificity. SSBs also aid genome metabolic processes through direct interactions with key proteins in genome maintenance enzymes. Single-Stranded DNA Binding Proteins: Methods and Protocols assembles methods developed for examining the fundamental properties of SSBs...
