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The DNA Damage Response: Implications on Cancer Formation and Treatment
The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal...
P.T. Usha
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Batukeshwar Dutt
Many Freedom fighters fought unselfishly for India’ s Independence. Some are known and famous while others are lost in oblivion. There were others who remained in the shadow of their partners. One such person was Batukeshwar; Bhaghat Singh’ s partner in the Assembly Bomb Case. Batukeshwar Dutt by Kumkum Khanna: Step into the courageous life of Batukeshwar Dutt, a revolutionary freedom fighter who played a pivotal role in India's struggle for independence. Kumkum Khanna's gripping biography unveils Dutt's daring act alongside Bhagat Singh during the famous Central Legislative Assembly bombing. With meticulous research, Khanna illuminates the lesser-known aspects of Dutt's life, portraying...
Biography of Major Dhyan Chand
Biography of Major Dhyan Chand: Inspirational Biographies for Children by Kumkum Khanna: This book is a biography of Major Dhyan Chand, one of India's most celebrated hockey players and a three-time Olympic gold medalist. The book recounts his life story, from his childhood in Allahabad to his accomplishments on the hockey field, and offers inspiration and encouragement to young readers. Key Aspects of the Book "Biography of Major Dhyan Chand: Inspirational Biographies for Children": Biography of Major Dhyan Chand: The book provides a biography of Major Dhyan Chand, highlighting his accomplishments on the hockey field. Inspirational: The book is intended to be inspirational and encouraging t...
Dada Bhai Nauroji
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Breast Cancer Research Protocols
A collection of both well-established and cutting-edge methods for investigating breast cancer biology not only in the laboratory, but also in clinical settings. These readily reproducible techniques solve a variety of problems, ranging from how to collect, store, and prepare human breast tumor samples for analysis, to analyzing cells in vivo and in vitro. Additional chapters address the technology of handling biopsies, new methods for analyzing genes and gene expression, markers of clinical outcome and progress, analysis of tumor-derived proteins and antigens, validating targets, and investigating the biology of newly discovered genes.
Tumor Suppressor Genes
It has become clear that tumors arise from excessive cell proliferation and a c- responding reduction in cell death. Tumors result from the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emphasis shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and tumor suppressor genes function in the same pathways, providing positive and ne- tive growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membr...
The Marigold Story
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Goal
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