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Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contribut...
Aimed primarily at clinicians who are required to find ways to interrupt patterns of destructive behaviour in couples and families, this text provides a compilation of multi-disciplinary techniques and flexible strategies to accomplish 14 major therapeutic tasks.
In Storyscapes we listen carefully to what South African writers reveal about themselves and their relations to South African space since the democratic transition of 1994. One main focus is the power of stories to uncover contradictory processes and investments of identity and to point readers toward a more meaningful life. Another main focus is the complexities of the post-colonial understanding of South African land, landscape, and space. Space in relation to race, class, and gender identity figures prominently in analyses and comparisons of diverse South African texts, such as Breyten Breytenbach's Dog Heart, André Brink's Imaginings of Sand, as well as the important South African subgenre of the farm novel. Questions of black or hybrid identity are highlighted by confronting older texts with new ones by black and women writers such as A.H.M. Scholtz and E.K.M. Dido. These texts - and a number of Afrikaans texts that are less well-known in the English-speaking world - are set in the wider frameworks of postcolonial criticism and global issues of cultural identity.
This accessible reference presents the evolution of concepts of time and methods of time keeping, for historians, scientists, engineers, and educators. The second edition has been updated throughout to describe twentieth- and twenty-first-century advances, progress in devices, time and cosmology, the redefinition of SI units, and the future of UTC.
El volumen 9 de la LEFIS Series celebra el 25 aniversario de BILETA (British & Irish Law, Education and Technology Association). En él, estudiosos internacionales pioneros en Informática y Derecho procedentes de universidades australianas, británicas, estadounidenses, holandesas, noruegas y españolas analizan los éxitos y desafíos en la aplicación de las tecnologías de información al Derecho y a la práctica legal.
Probabilistic Safety Assessment (PSA) is a structured, comprehensive, and logical analysis method aimed at identifying and assessing risks in complex technological systems, such as the nuclear power plants. It is also known as probabilistic risk assessment – PRA. This book presents the theoretical basis to understand the numerous and complex aspects that are covered by PSA and it will help the reader to better understand and to effectively manage risks. The book provides PSA methods and techniques and it includes recommended procedures that are based on the experience of the authors and applicable to different levels and types of PSA that are used for nuclear power plants applications. It can be used as extra reading for PSA courses for practitioners and it provides quantitative risk methodology documentation for PSA.
Commercial law judgments, South Africa
Mediation provides an attractive alternative to resolving disputes through court proceedings. Mediation promises just results in the interest of all parties concerned, a reduction of the court caseload, and cost savings for the parties involved as well as for the treasury. The European Directive on Mediation has given mediation in Europe new momentum by establishing a common framework for cross-border mediation. Beyond Europe, many states have tried in recent years to answer the question whether, and if so, how mediation should be regulated at a national and international level. The aim of this book is to promote the understanding and discussion of regulatory issues by presenting comparative...