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Biology of Apples and Pears is a comprehensive reference book on all aspects of pomology at the organ, tree and orchard level for researchers, students, fruit farmers and technical advisors. It describes the production of fruit with regard to key commercial factors, and under both temperate and tropical environmental conditions.
How sex hormone receptors and all the other members of the nuclear receptor superfamily do such a remarkable job has fascinated scientists for decades. A series of discoveries in the past few years has dramatically enlightened our understanding of the molecular mechanisms that govern nuclear receptor action. The elucidation of the 3D structures of several nuclear receptor ligand binding domains in the presence of agonists or antagonists has provided an allosteric concept of ligand action, and the discovery of a plethora of ligand-dependent protein interactions has linked this transconformation with the ability of nuclear receptors to act as transcriptional activators and repressors and the enzymatic modification of chromatin and factors of the basal transcriptional machinery.
This book is intended as a source of information for the many scientists who now enter the growing research field of vitamin A in health and disease, reviewing the epidemiological aspects related to vitamin A.
An authoritative introduction to plant responses and adaptation to the aerial environment, ideal for advanced undergraduate and graduate students.
Nuclear Receptors and Genetic Disease provides the first compilation of the role of nuclear hormones in health and disease and incorporates the latest breakthroughs in the field. It provides comprehensive reviews of the major receptors prepared by the acknowledged experts in each area. Each chapter provides information on the history, physiology, structure, mechanism of action, genetics, pathophysiology, disease diagnosis, and disease treatment for a particular nuclear receptor. Each chapter also includes a table showing all the known mutations of the respective nuclear receptor with the corresponding clinical disorder.Receptors included in this book are: - The Nuclear Receptor Superfamily - Thyroid Hormone Receptors - Estrogen and Progesterone Receptors - The Androgen Receptor - DAX-1 and Related Orphan Receptors - The Vitamin D Receptor - Retinoid Receptors - Mineralocorticoid and Glucocorticoid Receptors - Hepatocyte Nuclear Factor 4 a - Peroxisome Proliferator Activated Receptors - Coactivators and Corepressors
Are any of these plants dangerous, and do any of them really work? Where did they come from, and where are they available now? How can health-care practitioners gain the confidence of their patients to learn whether they are using alternative medicines for specific illnesses, symptoms, or injuries? Perhaps most intriguing, which of these plants might be waiting to take the place of known antibiotics as pathological organisms become increasingly resistant to modern miracle drugs?
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The past few years have witnessed the emergence of steroid hormones as the wonder molecules which generate as much discussion in the scientific literature as they do in a typical living room. This transition has been a result of the tremendous public and scientific interest in the normal functioning of the hor mones as well their suggested involvement in several clinical conditions. In the recent past, notable scientific and technological advances have been made in the areas of contraception and regulation of fertility. Steroid receptors are the indis pensable mediators of hormonal responses and are complex protein molecules which appear to exist in association with other, yet undefined, pro...
Despite the many benefits, the extensive use of chemicals and pharmaceutical products in agriculture, energy production, transportation, pharmaceuticals and other products can result in the inadvertent exposure of the fetus and the neonate. This text reviews the current knowledge of the pharmacokinetic characteristics, metabolism and renal handling of chemical and drugs in the fetus, lactating infant and newborn and goes on to deal with the fetus and the manner in which chemicals can affect the outcome of the newborn.