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Schlangengrube
In Hessen wird es giftig: Im 7. Teil ihrer Krimi-Reihe um Kommissarin Sabine Kaufmann machen die Bestseller-Autoren Daniel Holbe und Ben Tomasson die hessische Provinz buchstäblich zur Schlangengrube. Ein mysteriöser Fall beschäftigt die Kommissarin Sabine Kaufmann und ihren Kollegen Ralph Angersbach: In Hessen tauchen vermehrt geschmuggelte exotische Tiere auf, und in einer Transportkiste aus dem Amazonas-Gebiet liegt eine Tote. Dann wird Sabines LKA-Kollege Holger Rahn angegriffen und schwer verletzt. Hängen die Fälle zusammen? Erste Ermittlungsergebnisse führen die Kommissare auf die Spur von Umwelt-Aktivisten in Kolumbien – und tief in die Vergangenheit von Holger Rahn. Doch Rahns Verletzungen haben sein Gedächtnis beeinträchtigt, sodass er keine große Hilfe ist. Als er sich endlich zu erinnern beginnt, geschieht ein weiterer Mord ... Die raffinierte, hochspannende Krimi-Reihe um die hessischen Kommissare Sabine Kaufmann und Ralph Angersbach ist in folgender Reihenfolge erschienen: Giftspur Schwarzer Mann Sühnekreuz Totengericht Blutreigen Strahlentod Schlangengrube
Prognostic Impact and Diagnostic Value of Invasively Derived Hemodynamic Measures in Patients with Severe Aortic Stenosis Undergoing TAVI
Abstract: Background Ejection time (ET), acceleration time (AT) and time between left ventricular and aortic systolic pressure peaks (T-LVAo) might be of diagnostic and prognostic use in patients with aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI). Aim We aimed to assess the diagnostic value and prognostic impact of invasively measured ET, AT, and T-LVAo in patients undergoing TAVI. Methods A total of 1274 patients received invasive measurement of ET, AT and T-LVAo prior to TAVI. Anatomic AS severity was assessed by CT-derived aortic valve calcification density (AVCd). Impact on all-cause mortality was retrospectively analyzed. Results In multivariable linear regression, T-LVAo showed the strongest correlation with AVCd. No prognostic impact of T-LVAo was found according to uni- and multivariable analyses. In contrast, using an individual C-statistic derived cutoff (CD), patients with ET or AT ≥ CD showed lower mortality rates compared to patients with ET or AT CD (1-year mortality: ET ≥ vs. CD: 15.01vs. 33.1%, AT ≥ vs CD 16.3 vs. 26.5%, p
The Tumor Immunoenvironment
Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions.
Built to Lead: 7 Management R.E.W.A.R.D.S. Principles for Becoming a Top 10% Manager
Did you know that of every 100 employees hired, only 6 or 7 will ever be promoted to their first management position. If you're a manager now, and you probably are if you're reading this, "Congratulations!" You're one of the 7% who made it! That's the good news. Now, here's the bad news. Statistically speaking you won't be promoted again. The vast majority of these first time managers will eventually fail, and only 1 in 7 will stay in management with their present company for 5 years. Built to Lead is a "get-in-the-trenches with you, no-holds-barred" discussion about maximizing your ability to have an amazing management career. It tackles, head-on, the lies you've been told about how to reac...
The Grid 2
"The Grid" is an emerging infrastructure that will fundamentally change the way people think about and use computing. The editors reveal the revolutionary impact of large-scale resource sharing and virtualization within science and industry, and the intimate relationships between organization and resource sharing structures.
A Companion to the Poema de mio Cid
This volume brings together a number of distinguished scholars in the field of Poema de mio Cid studies. It provides an informed introduction to key literary aspects of the poem, and thoroughly examines many of the complex issues that are crucial for a comprehensive understanding of the work (historical context, ideological motivations, prosification in medieval chronicles, the poem’s place in the canon of Spanish literature). Equally important are the new findings that have been put forward since the 1970s, when scholars started to challenge Ramón Menéndez Pidal’s theories that had dominated the philological discourse since the beginning of the twentieth century. Contributors are Matthew Bailey, Simon Barton, Francisco Bautista, Juan Carlos Bayo Julve, Federico Corriente, Leonardo Funes, Luis Galván, Fernando Gómez Redondo, Eukene Lacarra Lanz, Salvatore Luongo, Georges Martin, Alberto Montaner, Javier Rodríguez Molina, Mercedes Vaquero, Roger Wright, and Irene Zaderenko.
Peritoneal Carcinomatosis: A Multidisciplinary Approach
This is the first volume to provide a multidisciplinary approach to peritoneal carcinomatosis encompassing molecular mechanisms, histopathology, regional and systemic cytotoxic therapy, and surgical options. Illustrations aid the reader throughout in the many facets of this disease. The book will be of particular interest for medical, surgical and gynecological oncologists faced with the complexities of decision making in patients suffering from PC.
Alinea
The debut cookbook from the restaurant Gourmet magazine named the best in the country. A pioneer in American cuisine, chef Grant Achatz represents the best of the molecular gastronomy movement--brilliant fundamentals and exquisite taste paired with a groundbreaking approach to new techniques and equipment. ALINEA showcases Achatz's cuisine with more than 100 dishes (totaling 600 recipes) and 600 photographs presented in a deluxe volume. Three feature pieces frame the book: Michael Ruhlman considers Alinea's role in the global dining scene, Jeffrey Steingarten offers his distinctive take on dining at the restaurant, and Mark McClusky explores the role of technology in the Alinea kitchen. Buye...
