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This book provides insights in to how high quality learning environments in Early Childhood Education and Care (ECEC) develop, and how competent systems can support this. It builds on the knowledge that quality early environments shape the wellbeing and development of the child, and explores how communities of professional practice that support quality development are built. Acknowledging that the conditions for providing high quality pedagogical work depend not only on the individual teacher, but also on collaboration and organizational and professional development. The book draws on a range of theoretical frameworks and research that underline competent systems rather than individualized learning as a path to improve workforce quality and professionalization in the field of ECEC.
Omfattende reformer af det bestående medfører som regel muligheder såvel som udfordringer. Folkeskolereformen er i denne forbindelse ingen undtagelse - artiklerne i nærværende seriehæfte diskuterer netop disse muligheder og udfordringer. Artiklerne er skrevet af forskere og ph.d.-studerende ved Laboratorium for forskningsbaseret skoleudvikling og pædagogisk praksis ved Aalborg Universitet. Seriehæftet henvender sig til samtlige aktører i og omkring folkeskolen, og vi håber, at artiklerne kan bidrage til konstruktive diskussioner af, hvordan en god folkeskole ser ud, og hvilke muligheder og udfordringer folkeskolereformen bringer
Der er skrevet og fortalt meget om byen Brønderslev, men ingen by uden borgere, iværksættere, handlende og os kunder. Det er den lille mand, der har gjort fabrikken eller forretningen stor, derfor har vi bestræbt os på at blande historierne så godt vi formåede ud af det der var tilgængeligt. Historierne er fra efter vuggen kommet løbende i løbet af en hundrede års periode. Vores bøger er fyldt med anekdoter og historier. Vi har ikke uden besvær måtte plukke en del historier fra, ellers ville bogen fylde hele bogreolen. Vi fik idéen til bøgerne, efter at have læst nogle interessante historier på, Brønderslev Fortiden i billeder og tekst og straks efter vi havde læst disse ...
En samling med mange spændende lokalhistoriske fortællinger fra forskellige steder i Vendsyssel. Alle mennesker rummer en historie. Denne bog indeholder Levnedsbeskrivelser korte og lange historier fra små bysamfund, nekrologer og mange spændende historier skrevet af forskellige personer, kendte som ukendte.
This volume provides informed arguments, theory and practical examples based on research about what it looks like when educators, policy makers, and even students, try to rethink and change their practices by engaging in evidence-based conversations to challenge and inform their work. It allows the reader to experience these conversations. Each story reveals the depth of thinking that change requires, showing that change requires new learning and new learning is hard.
Widely regarded as the definitive reference in the field, Youmans and Winn Neurological Surgery offers unparalleled, multimedia coverage of the entirety of this complex specialty. Fully updated to reflect recent advances in the basic and clinical neurosciences, the 8th Edition covers everything you need to know about functional and restorative neurosurgery, deep brain stimulation, stem cell biology, radiological and nuclear imaging, and neuro-oncology, as well as minimally invasive surgeries in spine and peripheral nerve surgery, and endoscopic and other approaches for cranial procedures and cerebrovascular diseases. In four comprehensive volumes, Dr. H. Richard Winn and his expert team of e...
The treatment of patients with advanced malignancies has undergone remarkable change in the last few years. While in the past decisions about systemic therapy were largely based on the performance status of a patient, oncologists today also take into account the pathological and molecular characteristics of the patient’s tumor. Targeting specific molecular pathways important for tumorigenesis has become the preferred way of treatment for many types of malignancies. With these advances come new challenges including the optimization of therapy, recognizing and dealing with side effects and, importantly, the development of resistance. This book provides an up-to-date overview of the advances and limitations of targeted therapy for several tumor entities including breast cancer, colon cancer, gastrointestinal stromal tumors, lung cancer, melanoma, ovarian cancer and renal cell carcinoma. Written by over a dozen internationally renowned scientists, the book is suitable for advanced students, postdoctoral researchers, scientists and clinicians who wish to update their knowledge of the latest approaches to targeted cancer therapies.
Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.