Molecular Analysis and Genome Discovery
  • Language: en
  • Pages: 391

Molecular Analysis and Genome Discovery

This advanced level textbook provides a comprehensive overview ofrecent developments in the area of molecular based diagnostics(including nucleic acids, biosensors and immunoessays) of diseasemarkers. It also covers the impact of techniques such as in vitronucleic acid amplifications (e.g. PCR) and other amplificationmethods, as well as gene and biochip production and automatedtechniques such as fluorescent sequencing. The book discusses key concepts where new and merging areas,including pharmacogenomics, proteomics and functional genomics, arebeing researched and developed. In addition, examples are givenwhere this new area of bioscience has or may be successfullyapplied.

Molecular Evolution
  • Language: en
  • Pages: 352

Molecular Evolution

The study of evolution at the molecular level has given the subject of evolutionary biology a new significance. Phylogenetic 'trees' of gene sequences are a powerful tool for recovering evolutionary relationships among species, and can be used to answer a broad range of evolutionary and ecological questions. They are also beginning to permeate the medical sciences. In this book, the authors approach the study of molecular evolution with the phylogenetic tree as a central metaphor. This will equip students and professionals with the ability to see both the evolutionary relevance of molecular data, and the significance evolutionary theory has for molecular studies. The book is accessible yet s...

An Introduction to Chemoinformatics
  • Language: en
  • Pages: 260

An Introduction to Chemoinformatics

  • Type: Book
  • -
  • Published: 2007-09-04
  • -
  • Publisher: Springer

This book aims to provide an introduction to the major techniques of chemoinformatics. It is the first text written specifically for this field. The first part of the book deals with the representation of 2D and 3D molecular structures, the calculation of molecular descriptors and the construction of mathematical models. The second part describes other important topics including molecular similarity and diversity, the analysis of large data sets, virtual screening, and library design. Simple illustrative examples are used throughout to illustrate key concepts, supplemented with case studies from the literature.

Bioinformatics
  • Language: en
  • Pages: 466

Bioinformatics

The heart of the book lies in the collaboration efforts of eight distinct bioinformatics teams that describe their own unique approaches to data integration and interoperability. Each system receives its own chapter where the lead contributors provide precious insight into the specific problems being addressed by the system, why the particular architecture was chosen, and details on the system's strengths and weaknesses. In closing, the editors provide important criteria for evaluating these systems that bioinformatics professionals will find valuable. * Provides a clear overview of the state-of-the-art in data integration and interoperability in genomics, highlighting a variety of systems and giving insight into the strengths and weaknesses of their different approaches.-

Enzyme Functionality
  • Language: en
  • Pages: 638

Enzyme Functionality

  • Type: Book
  • -
  • Published: 2003-10-28
  • -
  • Publisher: CRC Press

Enzyme Functionality serves as a conduit for trailblazing research in enzyme engineering-relating current understanding of sequence families, the new notion of enzyme structure classes, and modern methods in protein engineering, design, and directed evolution to accelerate the development of novel enzyme functionalities. This reference gathers the diverse perspectives of nearly 80 scientists from around the globe and surveys all leading rational and random approaches to the artificial evolution of enzymes. Citing more than 1500 notable works, it outlines assays for enzyme activity, stability, and specificity and a wide variety of site-directed, redesign, and evolutionary engineering methods.

Enzyme Technology
  • Language: en
  • Pages: 774

Enzyme Technology

Publisher Description

Isolation and Purification of Proteins
  • Language: en
  • Pages: 780

Isolation and Purification of Proteins

  • Type: Book
  • -
  • Published: 2003-02-05
  • -
  • Publisher: CRC Press

This publication details the isolation of proteins from biological materials, techniques for solid-liquid separation, concentration, crystallization, chromatography, scale-up, process monitoring, product formulation, and regulatory and commercial considerations in protein production. The authors discuss the release of protein from a biological host

Understanding Single-Crystal X-Ray Crystallography
  • Language: en
  • Pages: 826

Understanding Single-Crystal X-Ray Crystallography

The first textbook for teaching this method to users with little mathematical background logically presents the theory and fundamentals in an easily comprehensible, self-contained way. The result is a must-have for advanced undergraduate students, as well as masters and graduate students and other users of single-crystal X-ray crystallography from many various disciplines.

Genome Analysis: Current Procedures and Applications
  • Language: en
  • Pages: 398

Genome Analysis: Current Procedures and Applications

In recent years there have been tremendous achievements made in DNA sequencing technologies and corresponding innovations in data analysis and bioinformatics that have revolutionized the field of genome analysis.In this book, an impressive array of expert authors highlight and review current advances in genome analysis. This volume provides an invaluable, up-to-date and comprehensive overview of the methods currently employed for next-generation sequencing (NGS) data analysis, highlights their problems and limitations, demonstrates the applications and indicates the developing trends in various fields of genome research. The first part of the book is devoted to the methods and applications t...

Principles of Protein X-ray Crystallography
  • Language: en
  • Pages: 355

Principles of Protein X-ray Crystallography

New textbooks at all levels of chemistry appear with great regularity. Some fields such as basic biochemistry, organic reaction mechanisms, and chemical thermodynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from a real lack of up to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research that is advancing the field. It is not often easy to persuade such individuals t...