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Biobanks as Essential Tools for Translational Research: The Belgian Landscape
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Precision Vaccinology for Infectious Diseases
The Human body is a vast network of interacting genes, proteins, and metabolites. These components, which may be considered host factors, change under disease, treatment or healthy condition. While treatment of many diseases depends on therapeutic drugs, vaccines remain the most effective long-term public health intervention to prevent infectious diseases. To date, vaccines have been developed to treat entire populations with little provision for predisposing individual host factor differences. However, the use and application of vaccines is facing multiple challenges with increasing numbers of vaccine non-responders and vaccine-relapsed individuals. The cause of this complication is partially due to host-factors. Another challenge is the adverse effects of vaccines in patients with primary immunodeficiency or autoimmune diseases, as well as vaccine-waning immunity in ageing populations, obese populations, or those with co-infection. To overcome these challenges, the solution may be the design, and formulation of precision vaccines, which are patient-specific.
Autoimmune Diseases and Treatment
Drawing on the principles of immunology presented in Volume 1050, this volume extends these concepts to the realm of clinical findings and therapy for many autoimmune and connective tissue disorders.
Smart Sanctions: the Next Steps
Sanktionen sind das starkste nicht-militarische Zwangsinstrument, das den Vereinten Nationen zur Verfugung steht, um internationales Recht, Frieden und Sicherheit zu schaffen. In den 90er Jahren wurden mehr als ein Dutzend Sanktionen verhangt, allerdings mit unerwunschten Folgen fur die Bevolkerung - vor allem im Fall des Irak - einerseits und mangelhafter Umsetzung - insbesondere der Waffenembargos - andererseits. Im Auftrag des Auswartigen Amtes und in Zusammenarbeit mit dem Sekretariat der VN hat das Internationale Konversionszentrum Bonn (BICC) zwei groaere Tagungen und eine Reihe von Arbeitsgruppensitzungen durchgefuhrt, um insbesondere Vorschlage zur Verbesserung von Waffenembargos und...
