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The combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with its propensity to metastasize and to respond to therapy. It is not just one or a few genes, it is the complex alteration of the genome that determines cancer development and progression. Future management of cancer patients will therefore rely on thorough molecular analyses of each single case. Through this book, students, researchers and oncologists will obtain a comprehensive picture of what the first ten years of cancer genomics have revealed. Experts in the field describe, cancer by cancer, the progress made and its implications for diagnosis, prognosis and treatment of cancer. The deep impact on the clinics and the challenge for future translational research become evident.
This textbook is a practical guide to achieving professional-level audio productions using digital audio workstations. It contains 27 chapters divided into three sections, with specially devised diagrams and audio examples throughout. Aimed at students of all levels of experience and written in an easy-to-understand way, this book simplifies complex jargon, widening its appeal to non-academic creatives and is designed to accelerate the learning of professional audio processes and tools (software and hardware).The reader can work through the book from beginning to end or dip into a relevant section whenever required, enabling it to serve as both a step by step guide and an ongoing reference manual. The book is also a useful aid for lecturers and teachers of audio production, recording, mixing and mastering engineering.
A practical handbook for the beginner facilitator in applying Forum Theatre to community dialogue and conflict transformation. A facilitation manual to empower individuals and communities in responding to social issues using a non-judgemental and interactive approach.
Up-to-date, holistic and comprehensive discussion of public expenditure, its history, value for money, risks and remedies.
The Pacific Symposium on Biocomputing (PSB) 2010 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2010 will be held on January 4 - 8, 2010 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference. PSB 2010 will bring together top researchers from the US, Asia Pacific, and around the world to exchange research results and address pertinent issues in all aspects of computational biology. It is a forum ...
Jeff Diamanti describes the destructive relationship between climate and capital through the exponential growth of the petroleum industry over the last 40 years. Building on key insights in the environmental and energy humanities, Diamanti introduces the concept of the 'terminal landscape' as a site of storage, transformation and transition, essential to critical ecology in the 21st century. Climate and Capital in the Age of Petroleum presents these scenes of transformation as sites through which post-industrial capitalism distributes fossil fuels into the world. Diamanti uses this concept to redefine the post-industrial landscape by revealing the global flows of exchange and storage that pr...
Un’antologia divertente e scanzonata, uno zibaldone di storie per funamboli della lettura. Strizzando l’occhio all’umorista americano David Sedaris, Reggia traccia uno spazio lucido e surreale per chi ha voglia di tuffarsi nelle pagine di un libro bizzarro, scritto di notte ma da leggere rigorosamente di giorno, per sfuggire alla malinconia e accogliere il buonumore. Sono storie di lavoro, d’amore, di incontri sbagliati, allucinazioni notturne sempre in equilibrio precario tra reale e assurdo. Un ladruncolo sfigato, un narratore di poche parole, un feroce fancazzista-interistaleninista-tabagista: personaggi eccentrici, vitali e indimenticabili che ci invitano a variare continuamente punto di vista, per osservarci e osservare il mondo sovvertendo l’ovvio: così, il finale sarà sempre un colpo di scena. Il libro è poi corredato e completato dai pensieri molesti di Cicero: strambi e a volte enigmatici nonsense, che sbrogliano la comicità intelligente e disincantata dell’autore in una parodia grottesca della realtà.