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Cancer Genomics
The combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with its propensity to metastasize and to respond to therapy. It is not just one or a few genes, it is the complex alteration of the genome that determines cancer development and progression. Future management of cancer patients will therefore rely on thorough molecular analyses of each single case. Through this book, students, researchers and oncologists will obtain a comprehensive picture of what the first ten years of cancer genomics have revealed. Experts in the field describe, cancer by cancer, the progress made and its implications for diagnosis, prognosis and treatment of cancer. The deep impact on the clinics and the challenge for future translational research become evident.
Urban Air Quality in Europe
This book provides an overview of air quality in urban environments in Europe, focusing on air pollutant emission sources and formation mechanisms, measurement and modeling strategies, and future perspectives. The emission sources described are biomass burning, vehicular traffic, industry and agriculture, but also African dust and long-range transport of pollutants across the European regions. The impact of these emission sources and processes on atmospheric particulate matter, ozone, nitrogen oxides and volatile and semi-volatile organic compounds is discussed and critical areas for particulate matter and nitrogen dioxide in Europe are identified. Finally, this volume presents future perspectives, mainly regarding upcoming air quality monitoring strategies, metrics of interest, such as submicron and nanoparticles, and indoor and outdoor exposure scenarios.
The Nucleic Acid Protocols Handbook
A comprehensive treasury of all the key molecular biology methods-ranging from DNA extraction to gene localization in situ-needed to function effectively in the modern laboratory. Each of the 120 highly successful techniques follows the format of the much acclaimed Methods in Molecular BiologyOao series, providing an introduction to the scientific basis of each technique, a complete listing of all the necessary materials and reagents, and clear step-by-step instruction to permit error-free execution. Included for each technique are notes about pitfalls to avoid, troubleshooting tips, alternate methods, and explanations of the reasons for certain steps-all key elements contributing significantly to success or failure in the lab. The Nucleic Acid Protocols Handbook constitutes today's most comprehensive collection of all the key classic and cutting-edge techniques for the successful isolation, analysis, and manipulation of nucleic acids by both experienced researchers and those new to the field."
Encyclopedia of Renaissance Philosophy
Gives accurate and reliable summaries of the current state of research. It includes entries on philosophers, problems, terms, historical periods, subjects and the cultural context of Renaissance Philosophy. Furthermore, it covers Latin, Arabic, Jewish, Byzantine and vernacular philosophy, and includes entries on the cross-fertilization of these philosophical traditions. A unique feature of this encyclopedia is that it does not aim to define what Renaissance philosophy is, rather simply to cover the philosophy of the period between 1300 and 1650.
Cancer and the New Biology of Water
"When President Nixon launched the War on Cancer with the signing of the National Cancer Act of 1971 and the allocation of billions of research dollars, it was amidst a flurry of promises that a cure was within reach. The research establishment was trumpeting the discovery of oncogenes, the genes that supposedly cause cancer. As soon as we identified them and treated cancer patients accordingly, cancer would become a thing of the past. Fifty years later it's clear that the War on Cancer has failed--despite what the cancer industry wants us to believe. New diagnoses have continued to climb; one in three people in the United States can now expect to battle cancer during their lifetime. For the...
Encyclopaedia of Occupational Health and Safety
Intended as a resource for those who have responsibilities to safeguard workers' health and safety, especially in developing countries. Covers the fields of toxicology, occupational hygiene, occupational cancer, occupational diseases of agricultural workers, occupational safety, psycho- social problems and institutions and organizations active in the field of occupational health and safety.
