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Uma aventura estaminal
No conjunto de crónicas apresentadas neste livro, investigadores portugueses abordam um tema que tem revelado grandes avanços científicos e tecnológicos no âmbito da biomedicina: as células estaminais. Estas crónicas ilustradas foram publicadas mensalmente no jornal Diário de Coimbra entre Dezembro de 2011 e Maio de 2012 e resultaram de um projeto de divulgação científica designado "Quero Mais e Melhores Células! Células Estaminais: O que são? Onde estão? Para que servem?", uma iniciativa do Centro de Neurociências e Biologia Celular, Universidade de Coimbra (CNC), no âmbito do Programa COMPETE - Média Ciência. Este livro pretende contribuir para uma população mais infor...
Polyglutamine Disorders
This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s dise...
The Devil and the Land of the Holy Cross
Originally published in Brazil as O Diabo e a Terra de Santa Cruz, this translation from the Portuguese analyzes the nature of popular religion and the ways it was transferred to the New World in the sixteenth and seventeenth centuries. Using richly detailed transcripts from Inquisition trials, Mello e Souza reconstructs how Iberian, indigenous, and African beliefs fused to create a syncretic and magical religious culture in Brazil. Focusing on sorcery, the author argues that European traditions of witchcraft combined with practices of Indians and African slaves to form a uniquely Brazilian set of beliefs that became central to the lives of the people in the colony. Her work shows how the In...
Células estaminais: o que são? Onde estão? Para que servem?
No conjunto de crónicas apresentadas neste livro, investigadores portugueses abordam um tema que tem revelado grandes avanços científicos e tecnológicos no âmbito da biomedicina: as células estaminais. Estas crónicas ilustradas foram publicadas mensalmente no jornal Diário de Coimbra entre Dezembro de 2011 e Maio de 2012 e resultaram de um projeto de divulgação científica designado "Quero Mais e Melhores Células! Células Estaminais: O que são? Onde estão? Para que servem?", uma iniciativa do Centro de Neurociências e Biologia Celular, Universidade de Coimbra (CNC), no âmbito do Programa COMPETE - Média Ciência. Este livro pretende contribuir para uma população mais infor...
Constitutional Review in Western Europe
Recent confrontations between constitutional courts and parliamentary majorities in several European countries have attracted international interest in the relationship between the judiciary and the legislature. Some political actors have argued that courts have assumed too much power and politics has been extremely judicialized. Yet the extent to which this aggregation of power may have constrained the dominant political actors’ room for manoeuvre has never been examined accurately and systematically. This volume fills this gap in the literature. To explore the diversity and measure the strength of judicial decisions, the authors have elaborated a new methodology that is intended to give ...
Lentiviral Vectors
For the first time a compilation of chapters that depict the biological bases underlying the development of lentiviral vectors, the techniques involved in the manufacture of this new gene delivery tool, and its most promising applications.
Spinocerebellar Ataxia
The purpose of this book has been to depict as many biochemical, genetic and molecular advances as possible, in the vast field of the spinocerebellar ataxias.
Molecular Mechanisms Underpinning the Development of Obesity
Obesity is a multi-factorial disease, in which an excess of accumulated body fat can reach levels capable of affecting health. It results from an interplay between environmental factors, eating behavior, genes, epigenetics, and neuronal stimuli. The main aim of this book is to provide a state-of-the-art revision about the molecular mechanisms underpinning the development of obesity, reviewing the current knowledge in areas like monogenic and polygenic obesity forms, but also providing an updated view of the emerging knowledge about epigenetics, nutrigenomics, and neuronal aspects that also contribute to obesity.
Judicial Activism
This volume offers different perspectives on judicial practice in the European and American contexts, both arguably characterized in the last decades by the emergence of novel normative and even policy arguments by judges. The central question deserving the attention of the contributors concerns the degree in which judicial exercises in practical reasoning may amount to forms of judicial usurpation of the legislative function by courts. Since different views as to the nature and scope of legal reasoning lead to different degrees of tolerance regarding what should be admissible to courts, that same nature and scope is thoroughly debated. The main disciplinary approach is that of general jurisprudence, but the contributions take stock of other disciplines in which judicial activism has been addressed, namely positive theories of judicial behavior. Accordingly, the book also explores the development of interdisciplinary dialogue about the theme.
