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Lysosomes
Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development. • Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates • Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair • Introduces new pathways in therapeutic development and new mechanisms in drug development
Lysosomes
Covers the chief features of lysosomes at a useful level for students and researchers. Introduces fundamental concepts and terminology, presents historical perspective on the field, discusses heterophagy and autophagy, and reviews lysosome biogenesis. Annotation copyrighted by Book News, Inc., Portland, OR
Lysosomes
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Lysosomes
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Lysosomes
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Biology of the Lysosome
Updates the understanding of the biological and physiological role of the lysosomal system, furthering the effort to systemize the voluminous information being generated by research. The core section of the 12 review papers consider lysosome metabolism; other sections describe how the lysosome compo
Lysosomes
Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment. This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases. In addition to these classical topics, new insights into lysosomal functions are covered by chapters dealing with specialized lysosomes involved in bone resorption and plasma membrane repair, the lysosomal transciptome, and proteome and the emerging role of lysosomes in special forms of autophagy. This book will provide readers with a comprehensive overview into how this fascinating organelle works and how research in the field is developing.
Lysosomes and Cell Function
The lysosome system; Occurrence of lysosomes; Physiological functions of lysosomes: role of lusosomes in intracellular digestion; Physiological functions of lysosomes: role of lysosomes in secretion and extracellular digestion; role of lysosomes and acid hydrolases in developmental processes; Lysosomes in disease and injury.
Lysosomes
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Ion and Molecule Transport in Lysosomes
Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book discusses concepts and methods used to study lysosome ion and small molecule transport. The contents will not only attract accomplished investigators in need of a broad review and synthesis of this important subject but will also appeal to young investigators and trainees needing to acquire comprehensive knowledge and technical skills working with lysosomal ion channels and small molecule transporters. Key selling features: Summarizes the endocellular role that lysosomes play with respect to cellular waste disposal Reviews essential cellular functions of lysosomes Explores how lysosome dysfunction is the cause of many metabolic disorders Examines how lysomes are involved in storage diseases Describes various technologies and methods used in lysosome research
