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Suddenly Virtual
Supercharge your virtual meetings with evidence-based practices from an award-winning team The shift to virtual meetings was sudden and often traumatic for businesses across all industries as they responded to the global pandemic. Rather than focusing on what worked best, they focused on what worked now . . . which meant closing up the office and being suddenly virtual in nearly every meeting, often without the tools, the training, or the expertise to optimize the new “kitchen table” office. Thankfully, businesses are beginning to be more purposeful in both the tools they use and the approach they take. This book seeks to be a definitive guide for businesses looking to make their meeting...
Anti-Inflammatory Drug Discovery
A comprehensive review of recent medicinal chemistry approaches to a variety of important therapeutic targets and a key reference for those interested in the prosecution of modern drug discovery programs directed at anti-inflammatory mechanisms of action.
Molecular Biology of Brain and Endocrine Peptidergic Systems
We had the pleasure and the great opportunity to organize a symposium on "Molecular Biology of Brain and Endocrine Peptidergic Systems" under the auspices of the Canadian Biochemical society and the International Foundation for Biochemical Endocrinology. We were indeed very happy to ass~ble a series of first rate speakers who delivered excellent papers on a variety of subjects from the synthesis of complicated peptide analogs, to the creation of trangenic mice, site-directed mutagenesis, enzyme characterization and DNA binding sites. One hundred and seventy-five participants attended the 40 conferences while having the opportunity to look at 24 posters presented by senior scientists as well ...
Molecular Mechanisms of Signal Transduction
This book contains overviews of topics that have been discussed. It includes contributions from leading experts in the field on small GTPases, protein kinesis, receptors and transcription factors. A particular focus was the influence of oxygen radicals on signalling processes. It also contains the contributions of scientists early in their career, who have made an excellent contribution to the institute.
Protein Phosphorylation
Protein phosphorylation is a key mechanism in cellular signaling. This volume presents a state-of-the-art survey of one of the most rapidly developing fields of biochemical research. Written by leading experts, it presents the latest results for some of the most important cellular pathways. Color plates illustrate structural or functional relationships, numerous references provide links to the original literature.
Recombinant DNA Technologies in Neuroendocrinology
This volume covers new aspects and future directions in molecular neuroendocrinology, an important and rapidly growing area in neuroendocrinology. Among the various neurotransmitters or neuromodulators that play an important role in the control of endocrine functions, neuropeptides and related proteins have drawn special attention because of their diversity and complexity in action. More recently, molecular biology has become an essential tool of research in this area. Various genes encoding neuropeptides and other related pro- teins have been cloned, and the regulation of expression of these genes has been studied extensively. Transgenic animals have been used in studying the function of the gene in que- stion. In-situ hybridization is being applied to localize the site of production and analyze the regulation of pro- duction of peptides or proteins.
Men with Black Faces
About the Book Men with Black Faces chronicles the lives of coal miners, their difficult lives, and family struggles from 1880 through the Great Depression. As you learn the true stories of everyday life in the mining camps, the disaster and death, the great love they had for each other, and their dreams and ambitions, you will take away a better understanding of what life was really like in these communities and compare your life today with how it was at the dawn of the coal industry. About the Author Albert J. Thomas II is a graduate of Appalachian State University in North Carolina and received a master’s degree in curriculum and instruction from St. Vincent College in Latrobe, Pennsylvania. He grew up in a coal mining camp and spent a tour in Vietnam. He is an artist, is married to Kiti Roic from Croatia, and has two children. He decided to write this book to keep the coal miner’s legacy alive through all the backlash they receive from the green energy advocates. His life growing up in the coal mining patch of Filbert greatly assisted him in understanding his grandfather’s voice in this book.
Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles
Henry Jay Forman, Jon Fukuto and Martine Torres "Research is to see what everybody else has seen and to think what nobody else has thought. " -- Albert Szent-Gyorgyi Several years ago, one of us put together a book that dealt with various aspects of oxidative stress and introduced the concept of signal transduction by oxidants. Since then, the interest in the mechanisms by which reactive oxygen and nitrogen species (ROS/RNS) can modulate the cell’s response has tremendously grown, paralleling the intense efforts towards identifying new signaling pathways in which phosphorylation/dephosphorylation events take center stage. Evidence is now mounting that production of these species by the cel...
Signalling Molecules as Targets in Cancer Therapy
This book presents state-of-the-art information on the molecules of cell signalling pathways that represent actual or future targets for cancer therapy. By giving an update of the most promising approaches in this rapidly evolving field, the book contributes to the translation of the recent advances in the knowledge of intracellular signalling into the generation of innovative biomolecules as specific tools to target the most promising tumour-specific candidates. The book begins logically with the molecules first encountered along the signalling pathways, the membrane receptors for growth factors (Part I). Next, Part II presents several examples of intracellular molecular targets that are situated one step beyond in the pathways, while Part III addresses the difficult task of tuning the delicate balance between cell death and survival. In Part IV, the reader is taken into the practical problems raised by the therapy of specific cancers (glioma, childhood leukaemia), and into an original strategy from the field of nuclear medicine with the potential to generate innovative molecular-targeted cancer therapies.
