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A rare academic study on what John Rawls, Peter Singer and Derek Parfit acknowledge as the finest book in ethics – The Methods of Ethics. With a rather shocking conclusion that 'none of us can match Sidgwick', Mariko Nakano-Okuno lucidly analyzes Henry Sidgwick's impacts on contemporary ethics.
Though polychlorinated biphenyls (PCBs) have been banned in the United States for more than thirty years, the toxic effects of their presence in local environments continue to be a significant public health concern. PCBs: Human and Environmental Disposition and Toxicology brings together more than fifty established specialists on PCB toxicity to discuss recent trends and specialized investigations of PCB influences on the environment and on humans. Renowned scientists including Paul S. Cooke, Takeshi Nakano, Tomas Trnovec, Deborah C. Rice, Linda S. Birnbaum, and Charles S. Wong present cutting-edge research on Hudson River PCBs, human contamination, homologue profiles, high PCB exposure in Slovakia, and PCB effects on the thyroid hormone, nutrition, and estrogen levels in humans and animals. Focusing on the detection, movement, metabolism, toxicity, remediation, and risk assessment of PCB contamination, this multi-disciplinary study is a valuable resource for regulatory agencies and scientists working with PCBs.
Roger Crisp presents a comprehensive study of Henry Sidgwick's The Methods of Ethics, a landmark work first published in 1874. Crisp argues that Sidgwick is largely right about many central issues in moral philosophy: the metaphysics and epistemology of ethics, consequentialism, hedonism about well-being, and the weight to be given to self-interest. He holds that Sidgwick's long discussion of 'common-sense' morality is probably the best discussion of deontology we have. And yet The Methods of Ethics can be hard to understand, and this is perhaps one reason why, though it is a philosophical goldmine, few have ventured deeply into it. What does Sidgwick mean by a 'method'? Why does he discuss only three methods? What are his arguments for hedonism and for utilitarianism? How can we make sense of the idea of moral intuition? What is the role of virtue in Sidgwick's ethics? Crisp addresses these and many other questions, offering a fresh view of Sidgwick's text which will assist any moral philosopher to gain more from it.
The cancer stem cell (CSC) paradigm represents one of the most prominent breakthroughs of the last decades in tumor biology. CSCs are that subpopulation within a tumor that can survive conventional therapies and as a consequence are able to fuel tumor recurrence. Nevertheless, the biological characteristics of CSCs and even their existence, remain the main topic among tumor biologists debates. The difficulty in achieving a better definition of CSC biology may actually be explained by the plasticity of such a cell subpopulation. Indeed, the emerging view is that CSCs represent a dynamic “state” of tumor cells that can acquire stemness-related properties under specific circumstances, rathe...
About 7 million people worldwide are suffering from various inherited neuromuscular diseases. Gene therapy brings the hope of treating these diseases at their genetic roots. Muscle Gene Therapy is the only book dedicated to this topic. The first edition was published in 2010 when the field was just about to enter its prime time. The progress made since then has been unprecedented. The number of diseases that have been targeted by gene therapy has increased tremendously. The gene therapy toolbox is expanded greatly with many creative novel strategies (such as genome editing and therapy with disease-modifying genes). Most importantly, clinical benefits have begun to emerge in human patients. T...
A complete overview of bioprinting, from fundamentals and essential topics to recent advances and future applications Additive manufacturing, also known as 3D printing, is one of the most transformative technological processes to emerge in recent decades. Its layer-by-layer construction method can create objects to remarkably precise specifications with minimal waste or energy consumption. Bioprinting, a related process that employs cells and biomaterials instead of man-made substances or industrial materials, has a range of biomedical and chemical uses that make it an exciting and fast-growing area of research. 3D Bioprinting from Lab to Industry offers a cutting-edge overview of this topic...
As a scientific discipline, photochemistry generates more than 1200 articles and reviews a year across a range of fields. Keeping up with the literature can be difficult, but Specialist Periodical Reports present an informed view of the latest thinking and research in the field. The latest and 42nd volume in the series has a special emphasis on organic and computational aspects of photochemistry, drawn from the literature published in 2012 and 2013. Several chapters are devoted to comprehensive and critical reviews of various organic compounds and functional groups. One chapter is devoted to photoclick chemistry, another on continuous flow photochemical reactions. New methods for excited state energies and properties are also examined, as are new approaches to singlet oxygen photosensitisation in biological media and functions containing a heteroatom different from oxygen. Photochemistry provides essential reading for anyone wishing to keep up to date with the literature or gain a broad appreciation of the field.
Subject of the book is MR imaging in all kinds of diseases that may affect the skull and brain. Primary purpose of the book is to provide the reader with a descriptive as well as pictorial overview of MRI in the various pathologic processes. An important additional purpose is to explain how to make the best use of MRI if a particular disease is suspected. Extensive information on differential diagnosis will also be included.
Tests the views and metaphor of 19th-century utilitarian philosopher Henry Sidgwick against a variety of contemporary views on ethics, determining that they are defensible and thus providing a defense of objectivism in ethics and of hedonistic utilitarianism.