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Empirical Inference
This book honours the outstanding contributions of Vladimir Vapnik, a rare example of a scientist for whom the following statements hold true simultaneously: his work led to the inception of a new field of research, the theory of statistical learning and empirical inference; he has lived to see the field blossom; and he is still as active as ever. He started analyzing learning algorithms in the 1960s and he invented the first version of the generalized portrait algorithm. He later developed one of the most successful methods in machine learning, the support vector machine (SVM) – more than just an algorithm, this was a new approach to learning problems, pioneering the use of functional ana...
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Synthesis and Biological Evaluation of Pyrrole–Imidazole Polyamide Probes for Visualization of Telomeres
This book presents a novel method of synthesizing sequence-specific DNA binding pyrrole–imidazole (Py–Im) polyamides and demonstrates polyamides targeting longer base pairs than those previously reported and their cellular application. It discusses the development of the facile synthetic method of tandem hairpin Py–Im polyamides and the method of visualizing telomeres under mild conditions without harsh denaturation, as well as research resulting in the synthesis not only of previously reported tandem dimer polyamides but also longer tandem trimer and tetramer polyamides. Using fluorescently labeled tandem hairpin Py–Im polyamides targeting a human telomere repetitive sequence, the author successfully stained telomeres in fixed cells without denaturation. These fluorescently labeled tandem tetramer polyamides are able to visualize human telomeres with lower background signals than previous polyamide probes, suggesting that they have higher specificity for telomeres. As such, this book provides insights into recent advance in Py–Im polyamides, particularly the extension of the target sites c
Mechanisms of Heart Failure
Mechanisms of Heart Failure is based on papers selected from poster presentations made at the International Conference on Heart Failure, Winnipeg, May 20-23, 1994. Although the entire book is one continuous discussion of subcellular mechanisms of heart failure and its treatment, the presentation has been divided into three sections: the opening section on the subcellular basis of heart failure includes discussions of cytokines, signal transduction, metabolism, extracellular matrix, organ level changes and newer approaches to understanding the pathogenesis of heart failure. The second section focuses on the pathophysiological aspects of cardiomyopathies and their treatment. In the final section, medical, surgical and pharmacological approaches to the treatment of heart failure are discussed in clinical and animal laboratory settings.
Cell-Inspired Materials and Engineering
This book highlights cutting-edge studies in the development of cell-inspired biomaterials and synthetic materials that manipulate cell functions and provide the next generation with contemporary tools for treating complex human diseases. It explores the convergence of synthetic materials with cell and molecular biology and surveys how functional materials, when patterned with spatial and temporal precision, can be used effectively to maintain cell proliferation and phenotype in vitro, to trigger specific cell functions, and to redirect cell-fate decisions. Human stem cells are a frequently discussed subject in this book. This is an ideal book for students, cell biologists, researchers inter...
Waves And Stability In Continuous Media - Proceedings Of The 13th Conference On Wascom 2005
The book contains recent contributions in the field of waves propagation and stability in continuous media. In particular, the contributions consider discontinuity and shock waves, stability in fluid dynamics, small parameter problems, kinetic theories towards continuum models, non-equilibrium thermodynamics, and numerical applications.The volume is the fourth in a series published by World Scientific since 1999. The following distinguished authors contribute to the present book: S Bianchini, R Caflish, C Cercignani, Y Choquet-Bruhat, C Dafermos, L Desvillettes, V Giovangigli, H Gouin, I Muller, D Parker, B Straughan, M Sugiyama and W Weiss.
Advances in Heterocyclic Chemistry
Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area-one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties. - Up-to-date results in the subject which continues to gain importance and expand - Makes available to graduate students and research workers in academic and industrial laboratories the latest reviews on wide variety of heterocyclic topics - The series forms a very substantial database covering wide areas of heterocyclic chemistry
