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Genetics and Pathophysiology of Essential Hypertension
This book, authored by renowned researchers in the field of Hypertension Research, details the state of the art knowledge in genetics, genomics and pathophysiology of Essential hypertension, specifically the genetic determinants of hypertension and role of gene variants in response to anti-hypertensive therapy. Two chapters describe mitochondrial mutations in Essential hypertension and in hypertension associated Left ventricular hypertrophy, one chapter reviews in detail the global gene expression in hypertension, and an up to date treatise on pathophysiology of resistant hypertension is detailed in another chapter. Other topics included in the book are end organ damage, baroreceptor sensitivity and role of music therapy in essential hypertension.
Extracellular Matrix
Understanding extracellular matrix (ECM) structure and function is important for developing biomedical applications that are as close to ‘native’ as possible. Written by pioneering scientists from all over the world, this book reports research and new developments in the field of collagen structure, function, and biomechanics and discusses the relevance of hyaluronic acid and its therapeutic uses. It gives readers a glimpse of what is current in this area and we hope it piques their interest in learning more about ECM biology.
The Renin Angiotensin System in Cardiovascular Disease
This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonge...
Pharmacogenomics and Pharmacogenetics in Drug Therapy
The genetic makeup of a person has been found to influence their response to several drugs. Pharmacogenetics and pharmacogenomics provide useful information in this respect and are important tools for tailoring personalized and precision medicine. This book provides recent literature on the role of genetic variants in drug response in some drug therapies. It includes an introductory chapter giving an overview of the role of the pharmacogenomics and pharmacogenetics of various drug therapies in different diseases such as cardiovascular disease, psychiatric disorders, and cancers. The book also includes chapters on the pharmacogenetics of aspirin, type 2 diabetes, the human Nat2 gene, and cardiovascular diseases. We hope that the book will provide useful information to clinicians and basic scientists on the selected topics.
Atherosclerotic Cardiovascular Disease
Cardiovascular diseases (CVD) are still one of the leading causes of death in the world. The book Atherosclerotic Cardiovascular Disease is a contribution to the application of new knowledge in the area of cardiovascular diseases. The book comprises six chapters divided in three subsections, starting with the General Considerations of Cardiovascular Disease, through Diagnostic Techniques, and Specific Therapy.
