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Biochemistry of Lipids, Lipoproteins and Membranes
Research on the biochemistry and molecular biology of lipids and lipoproteins has experienced remarkable growth in the past 20 years, particularly with the realization that many different classes of lipids play fundamental roles in diseases such as heart disease, obesity, diabetes, cancer and neurodegenerative disorders. The 5th edition of this book has been written with two major objectives. The first objective is to provide students and teachers with an advanced up-to-date textbook covering the major areas of current interest in the lipid field. The chapters are written for students and researchers familiar with the general concepts of lipid metabolism but who wish to expand their knowledg...
Awareness shaping or shaped by prediction and postdiction
We intuitively believe that we are aware of the external world as it is. Unfortunately, this is not entirely true. In fact, the capacity of our sensory system is too small to veridically perceive the world. To overcome this problem, the sensory system has to spatiotemporally integrate neural signals in order to interpret the external world. However, the spatiotemporal integration involves severe neural latencies. How does the sensory system keep up with the ever-changing external world? As later discussed, ‘prediction’ and ‘postdiction’ are essential keywords here. For example, the sensory system uses temporally preceding events to predict subsequent events (e.g., Nijhawan, 1994; Ker...
Forming the Future
In this collection, scientists and engineers from across industry, academia, and government present their latest improvements and innovations in all aspects of metal forming science and technology, with the intent of facilitating linkages and collaborations among these groups. Chapters cover the breadth of metal forming topics, from fundamental science to industrial application.
Explosion Shock Waves and High Strain Rate Phenomena
The book presents the papers presented at the 6th international conference on Explosion, Shock Wave and High Strain-Rate Phenomena (ESHP). Topics covered include: Advanced Manufacturing under Impact/Shock Loading, Detonation of High Pressure Flammable Gas in Closed Spaces, High Strain-Rate Behaviour of Auxetic Cellular Structures, Underwater Shock Waves Generation, Magnetic Pressure Welding of Aluminum Sheets, Shock Synthesis of Zirconium Oxides, Impact Joining of Dissimilar Metals, High-Speed Oblique Collision of Metals, Dynamic Behavior of Dislocation Wall Structures, Tensile Strength of Rock at High Strain Rates, Fiber Reinforced Mortar, Impact Analysis of Carbon Fiber Reinforced Polymer, Explosive Welding , Underwater Explosive Welding , Making Ultrafine Explosives, Aluminum-Steel Explosive Cladding, Explosively Cladded Aluminum Hybrid Composites, Explosive Clads with Interlayers.
Time Perception and Dysfunction: Clinical and Practical Implications
Processing time requires a complex set of abilities that dictates how one adapts to the environment. Timing is key in how we communicate, organize our space and understand the world. When timing is intact, it often exists below one's conscious awareness, but when one's ability to process time is disrupted, the effects are noticeable and widespread. To better understand the construct of temporal dysfunction, one has to examine the concept of timing from multiple angles. An integrative approach is required to understand the possible biological, cognitive and psychological etiologies of temporal dysfunction. In addition, expertise in language, measurement and psychopathology are necessary to co...
Stearoyl-CoA Desaturase Genes in Lipid Metabolism
Obesity and diabetes develop as a complex result of genetic, metabolic and environmental factors and are characterized by increased lipogenesis and lipid accumulation in many tissues. Stearoyl-CoA desaturase (SCD) genes are a critical regulator of lipogenesis and catalyzes the synthesis of monounsaturated fatty acids (MUFA), mainly oleoyl- (18:1n9) and palmitoleoyl-CoA (16:1n7). These MUFAs are the major fatty acid substrates for the synthesis of triglycerides, cholesterol esters, wax esters and membrane phospholipids. There are 4 SCD isoforms (SCD1-4) in mice and two (hSCD1 and hSCD5) expressed in humans. At first glance, stearoyl-CoA desaturase enzyme would be considered a housekeeping enz...
The Peroxidase Multigene Family of Enzymes
In September 1998 experts from 19 countries came together for an interdisciplinary discussion of the function of animal peroxidases, a family of enzymes embracing myeloperoxidase, eosinophil peroxidase, thyroid peroxidase and lactoperoxidase. Their papers have been updated for publication, yielding a wide-ranging overview of the state of the art. The chapters cover a wide range of topics, including three-dimensional structure of representative family members, their biosynthesis and intracellular transport, mechanism of action as well as applications to clinical medicine. They are of clinical relevance in, for example, arteriosclerosis, multiple sclerosis, infections, tumorigenesis, rheumatic diseases and hypothyroidism. This book forms an excellent introduction for anyone interested in the peroxidase family of enzymes.
