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Cytoskeleton
The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.
Cell Death
This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.
AMP-activated Protein Kinase
AMPK has emerged as an important integrator of signals that control energy balance through the regulation of multiple biochemical pathways in eukaryotes. This book focuses on the implications of AMPK as a master metabolic regulator in diseases, including new methods and animal models. The contributions are written by leading experts in the field and give an extensive overview of the current knowledge of AMPK biology and the role of AMPK in health and disease.
Chemically-Induced DNA Damage, Mutagenesis, and Cancer
This book is a printed edition of the Special Issue " Chemically-Induced DNA Damage, Mutagenesis, and Cancer" that was published in IJMS
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections. Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinso...
Autophagy
Coenzyme Q10 (CoQ) deficiencies are clinically and genetically heterogeneous diseases that can occur due to defects of ubiquinone biosynthesis (primary deficiencies) or other causes (secondary deficiencies). Radical oxygen species (ROS) production and oxidative stress is a common consequence of dysfunctional mitochondria and CoQ deficiency. Mitochondrial damage induced by ROS can trigger mitochondrial permeability transition (MPT) by opening of non-specific high conductance permeability transition pores in the mitochondrial inner membrane. This, in turn, leads to a simultaneous collapse of mitochondrial membrane potential and the activation of selective elimination of depolarized and dysfunctional mitochondria by mitophagy. In this respect, mitophagy could be considered as a protective mechanism for elimination of potential harmful mitochondria. Mitophagy must be accompanied by mitochondrial biogenesis activation to compensate the mitochondrial loss. However, massive and persistent mitophagy may impair cell bioenergetics, autophagy flux, and mitochondrial biogenesis, and eventually may cause cell death.
Santa Bárbara’s Legacy
In Santa Bárbara’s Legacy: An Environmental History of Huancavelica, Peru, Nicholas A. Robins presents the first comprehensive environmental history of a mercury producing region in Latin America. Tracing the origins, rise and decline of the regional population and economy from pre-history to the present, Robins explores how people’s multifaceted, intimate and often toxic relationship with their environment has resulted in Huancavelica being among the most mercury-contaminated urban areas on earth. The narrative highlights issues of environmental justice and the toxic burdens that contemporary residents confront, especially many of those who live in adobe homes and are exposed to mercury, as well as lead and arsenic, on a daily basis. The work incorporates archival and printed primary sources as well as scientific research led by the author.
Trans-Atlantic Passenger Ships, Past and Present
A comprehensive guide to the history and technology of transatlantic passenger ships. This book covers the earliest steam-powered liners, through the great ocean liners of the early 20th century, and up to the modern cruise ships of today. With photographs, diagrams, and detailed descriptions of the ships and their voyages, this book is a must-have for anyone interested in the history of ocean travel. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Converso Non-Conformism in Early Modern Spain
This book examines the effects of Jewish conversions to Christianity in late medieval Spanish society. Ingram focuses on these converts and their descendants (known as conversos) not as Judaizers, but as Christian humanists, mystics and evangelists, who attempt to create a new society based on quietist religious practice, merit, and toleration. His narrative takes the reader on a journey from the late fourteenth-century conversions and the first blood purity laws (designed to marginalize conversos), through the early sixteenth-century Erasmian and radical mystical movements, to a Counter-Reformation environment in which conversos become the advocates for pacifism and concordance. His account ends at the court of Philip IV, where growing intolerance towards Madrid’s converso courtiers is subtly attacked by Spain’s greatest painter, Diego Velázquez, in his work, Los Borrachos. Finally, Ingram examines the historiography of early modern Spain, in which he argues the converso reform phenomenon continues to be underexplored.
AMPK
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