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Autophagy
Coenzyme Q10 (CoQ) deficiencies are clinically and genetically heterogeneous diseases that can occur due to defects of ubiquinone biosynthesis (primary deficiencies) or other causes (secondary deficiencies). Radical oxygen species (ROS) production and oxidative stress is a common consequence of dysfunctional mitochondria and CoQ deficiency. Mitochondrial damage induced by ROS can trigger mitochondrial permeability transition (MPT) by opening of non-specific high conductance permeability transition pores in the mitochondrial inner membrane. This, in turn, leads to a simultaneous collapse of mitochondrial membrane potential and the activation of selective elimination of depolarized and dysfunctional mitochondria by mitophagy. In this respect, mitophagy could be considered as a protective mechanism for elimination of potential harmful mitochondria. Mitophagy must be accompanied by mitochondrial biogenesis activation to compensate the mitochondrial loss. However, massive and persistent mitophagy may impair cell bioenergetics, autophagy flux, and mitochondrial biogenesis, and eventually may cause cell death.
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections. Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinso...
Foundations of Fuzzy Logic and Soft Computing
This book comprises a selection of papers from IFSA 2007 on new methods and theories that contribute to the foundations of fuzzy logic and soft computing. Coverage includes the application of fuzzy logic and soft computing in flexible querying, philosophical and human-scientific aspects of soft computing, search engine and information processing and retrieval, as well as intelligent agents and knowledge ant colony.
Drug Utilization Research
Drug Utilization Research (DUR) is an eclectic scientific discipline, integrating descriptive and analytical methods for the quantification, understanding and evaluation of the processes of prescribing, dispensing and consumption of medicines and for the testing of interventions to enhance the quality of these processes. The discipline is closely related and linked mainly to the broader field of pharmacoepidemiology, but also to health outcomes research, pharmacovigilance and health economics. Drug Utilization Research is a unique, practical guide to the assessment and evaluation of prescribing practices and to interventions to improve the use of medicines in populations. Edited by an international expert team from the International Society for Pharmacoepidemiology (ISPE), DUR is the only title to cover both the methodology and applications of drug utilization research and covers areas such as health policy, specific populations, therapeutics and adherence.
Fighting for Abortion Rights in Latin America
Although they share similar socio-economic and cultural characteristics as well as their recent political histories, Argentina, Chile and Uruguay differ radically in their abortion policies. In this book, Cora Fernández Anderson examines the role social movements play in abortion reform to show how different interaction patterns with state actors have led to three different policy outcomes: comprehensive abortion reform in Uruguay; moderate abortion reform in Chile; and no legal abortion reform in Argentina. Synthesizing a broad range of literature and drawing on in-depth field and archival research, she analyzes the strength of the campaigns for abortion reform, their relationships with leftist parties in power and the context of Church–state relations to explain this diverging trajectory in policy reform. A masterly analysis of how social movements, the power of institutions and Executive preferences have strong explanatory power, Fighting for Abortion Rights in Latin America is a perfect supplement for classes on gender and global politics.
Am I the Only One (Sheet Music)
(Piano Vocal). This sheet music features an arrangement for piano and voice with guitar chord frames, with the melody presented in the right hand of the piano part, as well as in the vocal line.
Billboard
In its 114th year, Billboard remains the world's premier weekly music publication and a diverse digital, events, brand, content and data licensing platform. Billboard publishes the most trusted charts and offers unrivaled reporting about the latest music, video, gaming, media, digital and mobile entertainment issues and trends.
Switched on Pop
Based on the critically acclaimed podcast that has broken down hundreds of Top 40 songs, Switched On Pop dives in into eighteen hit songs drawn from pop of the last twenty years--ranging from Britney to Beyoncé, Kelly Clarkson to Kendrick Lamar--uncovering the musical explanations for why and how certain tracks climb to the top of the charts. In the process, authors Charlie Harding and Nate Sloan reveal the timeless techniques that animate music across time and space.
The Rough Guide to Spain
Presents a guide to traveling in Spain, providing an introduction to the country with advice on planning a visit, and discussing the attractions, restaurants, accommodations, shopping, and entertainment venues of Madrid and other cities and regions. Includes maps and photographs.
Stripped: Depeche Mode
An electrifying new biography about the four Essex lads who became award-winning stadium superstars and champions of synth pop! Jonathan Miller's groundbreaking book features in-depth interviews with founder member Vince Clarke and producers Gareth Jones and Mark Bell, and contains never-before seen interviews with the band members themselves. With additional input from Gary Human, Howard Jones and Thomas Dolby this is a unique portrait of a band that almost lost control when their lives went off the rails and lead singer Dave Gahan's heroin addiction nearly killed him. In the end Depeche Mode not only survived, they triumphed, racking up a staggering 40 million-plus album sales on the way. ...
