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Estratégias de promoção de saúde são complexas e necessitam de atenção dos profissionais no planejamento de intervenções inovadoras, que de fato contribuam para melhorar a saúde e a qualidade de vida da população a que se destina. Esta obra, de quatro capítulos, discute uma temática fundamental para transformações das práticas de saúde na área do Ensino, transferindo conhecimentos gerados pela universidade federal ao sistema público de saúde na região norte do Brasil. Que os relatórios técnicos, contidos no presente e-book, sejam capazes de aguçar nos leitores uma infinidade de inquietações, diálogos e perspectivas. Portanto, desejamos que vocês, discentes, docentes, pesquisadores em geral, profissionais de saúde e demais interessados sobre ensino e formação em saúde, recebam com carinho esta obra.
From first principles to real-world applications -- here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines--from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and development...
The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Thro...
The Neuquen Basin of northern Patagonia provides an excellent case study in basin analysis and sequence stratigraphy. The basin is one of the largest petroleum provinces in South America and includes a dramatic record of relative sea level changes as well as a unique and globally important palaeontological record. Understanding this region is also central to unravelling the history of the Andes. The latest developments in the study of the area have been combined in this volume to give an integrated series of case studies that document the structural, igneous, sedimentological and palaeontological history of the region from the Triassic to the Recent. This publication provides an introduction into this fascinating region as well as a resource that includes the most complete and up-to-date studies of the area.
Situates the cultures of Portuguese-speaking Africa within the postcolonial, global era.
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This book presents the Proceedings of The 6th Brazilian Technology Symposium (BTSym'20). The book discusses the current technological issues on Systems Engineering, Mathematics and Physical Sciences, such as the Transmission Line, Protein-Modified Mortars, Electromagnetic Properties, Clock Domains, Chebyshev Polynomials, Satellite Control Systems, Hough Transform, Watershed Transform, Blood Smear Images, Toxoplasma Gondi, Operation System Developments, MIMO Systems, Geothermal-Photovoltaic Energy Systems, Mineral Flotation Application, CMOS Techniques, Frameworks Developments, Physiological Parameters Applications, Brain–Computer Interface, Artificial Neural Networks, Computational Vision,...
The 4th volume of this comprehensive work features hundreds of serial killers from Sacramento to Soviet Russia—plus numerous unsolved cases. The World Encyclopedia of Serial Killers is the most complete reference guide on the subject, featuring more than 1,600 entries about the lives and crimes of serial killers from around the world. Defined by the FBI as a person who murders three or more people with a hiatus of weeks or months between murders, the serial killer has presented unique and terrifying challenges to have walked among us since the dawn of time—a fact this extensive record makes chillingly clear. The series concludes with Volume Four, T-Z. Entries include the Terminator Anatoly Yuriyovych Onoprienko; Trailside Killer David Joseph Carpenter; Vampire of Sacramento Richard Trenton Chase; and the Voroshilovgrad Maniac Zaven Almazyan; plus the unsolved cases of the Adelaide Child Murders; the Axeman of New Orleans; the Chillicothe Killer; the Dead Women of Juarez; the Korea Frog Boy Murders; and the Volga Maniac.
Understanding how the brain functions is one of the most ambitious current scientific goals. This challenge will only be accomplish by a multidisciplinary approach involving genetics, molecular biology, optics, ethology, neurobiology and mathematics and using tractable model systems. The zebrafish larva is a transparent genetically tractable small vertebrate, ideal for the combination state-of-the- art imaging techniques (e.g. two-photon scanning microscopy, single-plane illumination microscopy, spatial light modulator microscopy and lightfield microscopy), bioluminiscence and optogenetics to monitor and manipulate neuronal activity from single specific neurons up to the entire brain, in an intact behaving organism. Furthermore, the zebrafish model offers large and increasing collection of mutant and transgenic lines modelling human brain diseases. With these advantages in hand, the zebrafish larva became in the recent years, a novel animal model to study neuronal circuits and behaviour, taking us closer than ever before to understand how the brain controls behaviour.
We explore the impact of major labor and product market reforms on current account dynamics using a new “narrative” database of major changes in employment protection for regular workers and product market regulation for non-manufacturing industries covering 26 advanced economies over the past four decades. Our main finding is that product market deregulation is associated with a weakening of the current account, while labor market deregulation is associated with an improvement. These effects are transitory and driven by both saving and investment responses. Labor and product market reforms both have a more positive impact on the current account balance when implemented under weak macroeconomic conditions. Our results are broadly consistent with predictions from recent DSGE models with endogenous producer entry and labor market frictions.