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Ciências Policiais de Segurança e Ordem Pública
A cada dia que passa cresce a dificuldade de resolução dos atuais problemas sociais. Da mesma forma que a nossa sociedade se tornou mais complexa devido ao avanço tecnológico constante, as ciências também evoluíram. Problemas, que antes eram estudados e resolvidos simplesmente com a aplicação dos princípios, métodos e valores das ciências tradicionais, não são mais facilmente aplicáveis às situações modernas. Dentro desse contexto, podem e devem ser inseridos os problemas sociais que envolvem a ordem pública e, principalmente, o seu elemento segurança pública. Essas questões que tanto afligem a sociedade não podem mais ser estudadas unicamente através de ciências tra...
Sustainable Chemistry Research
This edited book of proceedings is a collection of twelve selected and peer-reviewed contributions from the Virtual Conference on Chemistry and its Applications (VCCA-2022). VCCA-2022 was held online from 8th to 12th August 2022. The theme of the conference was "Resilience and Sustainable Research through Basic Sciences". 500 participants from 55 countries participated in VCCA-2022. This volume 3 reflects the chapters covering analytical aspects.
Small Molecule Medicinal Chemistry
Stressing strategic and technological solutions to medicinal chemistry challenges, this book presents methods and practices for optimizing the chemical aspects of drug discovery. Chapters discuss benefits, challenges, case studies, and industry perspectives for improving drug discovery programs with respect to quality and costs. • Focuses on small molecules and their critical role in medicinal chemistry, reviewing chemical and economic advantages, challenges, and trends in the field from industry perspectives • Discusses novel approaches and key topics, like screening collection enhancement, risk sharing, HTS triage, new lead finding approaches, diversity-oriented synthesis, peptidomimetics, natural products, and high throughput medicinal chemistry approaches • Explains how to reduce design-make-test cycle times by integrating medicinal chemistry, physical chemistry, and ADME profiling techniques • Includes descriptive case studies, examples, and applications to illustrate new technologies and provide step-by-step explanations to enable them in a laboratory setting
Organic Reactions, Volume 112, Parts A and B
Band 112 der Reihe Organic Reactions enthält einen sorgfältig kuratierten Überblick über die wissenschaftliche Literatur zum 50-jährigen Jubiläum der Ugi-Reaktion. Es werden die praktischen und theoretischen Aspekte einer der am häufigsten genutzten Reaktionen in der organischen Chemie betrachtet, wobei sowohl die eigentliche Ugi-Reaktion als auch ihre zahlreichen Varianten im Fokus stehen. Dieser Band wird in zwei Teilen (A und B) herausgebracht. Die bereits seit 1942 erscheinende Reihe Organic Reactions zählt im Bereich der organischen Chemie weltweit zu den führenden Sekundär- und Tertiärquellen.
Multicomponent Reactions
In the very first book on this hot topic, the expert editors andauthors present a comprehensive overview of these elegantreactions. From the contents: Organoboron compounds Free-radical mediated multicomponent coupling reactions Applications in drug discovery Metal catalyzed reactions Total synthesis of natural products Asymmetric isocyanide-based reactions The Biginelli reaction Asymmetric isocyanide-based reactions The Domino-Knoevenagel-Hetero-Diels-Alder Reaction and relatedtransformations Catalytic asymmetric reactions Algorithm based methods for discovering novel reactions Post-condensation modifications of the Passerini and Ugireactions An essential reference for organic and catalytic chemists, andthose working in organometallics both in academia and industry.
Domino Reactions in Organic Synthesis
Domino reactions enable you to build complex structures in one-pot reactions without the need to isolate intermediates- a dream comes true. In this book, the well-respected expert, Professor Lutz Tietze, summarizes the possibilities of this reaction type - an approach for an efficiant, economically benificial and ecological benign synthesis. A definite must for every organic chemist.
Viruses and Human Cancer
This book, in a new, extensively updated edition, covers viral infection, virus-induced inflammation and tissue injuries, viral epidemiology, oncogenic mechanisms, and current and emerging preventive and therapeutic strategies in detail. Readers will also find information on the individual aspects of a number of oncogenic viruses, including hepatitis B, hepatitis C, human papillomavirus, Epstein–Barr virus, human T-cell lymphotropic virus, Kaposi sarcoma-associated herpes, and Merkel cell polyomavirus, as well as associated human cancers. The book will benefit all those who are seeking a comprehensive, up-to-date overview of the basic and clinical aspects of oncogenic viruses and associated human cancers. Following its original publication in 2014, the first edition of this book quickly became an influential text in the field. This second edition duly reflects the significant advances in knowledge and research that have been achieved in the years since.
Computational Diffusion MRI
This volume gathers papers presented at the Workshop on Computational Diffusion MRI (CDMRI 2019), held under the auspices of the International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI), which took place in Shenzhen, China on October 17, 2019. This book presents the latest advances in the rapidly expanding field of diffusion MRI. It shares new perspectives on the latest research challenges for those currently working in the field, but also offers a valuable starting point for anyone interested in learning about computational techniques in diffusion MRI. The book includes rigorous mathematical derivations, a wealth of rich, full-colour visualisations and...
Practical Medicinal Chemistry with Macrocycles
Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations
Synthesis of Heterocycles via Multicomponent Reactions I
Contents: L. Banfi ∙ A. Basso ∙ R. Riva: Synthesis of Heterocycles Through Classical Ugi and Passerini Reactions Followed by Secondary Transformations Involving One or Two Additional Functional Groups.- V.A. Chebanov ∙ K. A. Gura ∙ S.M. Desenko: Aminoazoles as Key Reagents in Multicomponent Heterocyclizations.- Y. Huang ∙ K. Khoury ∙ A. Dömling: Piperazine Scaffolds by Multicomponent 3 Reactions: The Piperazine Space 4 in MCR Chemistry 5 Deep MCR Piperazine Space.- N. Elders ∙ E. Ruijter ∙ V.G. Nenajdenko ∙ R.V.A. Orru: α-Acidic Isocyanides in Multicomponent Chemistry.- A. Cukalovic ∙ J.-C.M.R. Monbaliu ∙ C.V. Stevens: Microreactor Technology as an Efficient Tool for Multicomponent Reactions.- L.A. Wessjohann ∙ C.R.B. Rhoden ∙ D.G. Rivera ∙ O. Eichler Vercillo: Cyclic Peptidomimetics and Pseudopeptides from Multicomponent Reactions.- M. del Mar Sanchez Duque ∙ C. Allais ∙ N. Isambert ∙ T. Constantieux ∙ J. Rodriguez: ß-Diketo Building Blocks for MCRs-Based Syntheses of Heterocycles
