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Cellular Senescence
This book describes current methods for the identification and characterization of the major hallmarks of senescent cells. Chapters focus on the high heterogeneity of the senescence phenotypes, and techniques to induce and identify specific senescence programs. Additional chapters describe cellular and mouse models in which is possible to study the complex cell and non-cell autonomous functions of senescent cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cellular Senescence: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Senolytics in Disease, Ageing and Longevity
This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the number of persons aged 80 years or older is expected to triple, from 143 million in 2019 to 426 million in 2050. First documented in the 1960s, the concept of cellular senescence as an unde...
Degrowth
Degrowth is a rejection of the illusion of growth and a call to repoliticize the public debate colonized by the idiom of economism. It is a project advocating the democratically-led shrinking of production and consumption with the aim of achieving social justice and ecological sustainability. This overview of degrowth offers a comprehensive coverage of the main topics and major challenges of degrowth in a succinct, simple and accessible manner. In addition, it offers a set of keywords useful forintervening in current political debates and for bringing about concrete degrowth-inspired proposals at different levels - local, national and global. The result is the most comprehensive coverage of the topic of degrowth in English and serves as the definitive international reference. More information at: vocabulary.degrowth.org View the author spotlight featuring events and press related to degrowth at http://t.co/k9qbQpyuYp.
The Death of Death
Is death inevitable? Until now, the history of mankind has been marked by this fatal fact. Religions, borders and progress are born from an ancient fear of death, comfort from this fear man often found only in religious paradigms. But according to José Luis Cordeiro and David Wood, the incontrovertible fact of death is no longer an absolute certainty - science and technology are preparing to tear down the final frontier: that of immortality. This accessible book provides insight into recent exponential advances in artificial intelligence, tissue regeneration, stem cell treatment, organ printing, cryopreservation, and genetic therapies that, for the first time in human history, offer a reali...
The Pain Solution
DISCOVER A PROVEN PATH TO PAIN RELIEF With empathy and scientific savvy, pain expert Dr. Saloni Sharma offers a personalized and innovative five-step pain relief program built on what she calls “microboosts,” little steps that add up to big results. Illustrated with inspiring patient examples and personal stories, her drug-free plan will enable you to: • understand the unique factors contributing to your pain • develop a path to resuming your most cherished activities • add easy food microboosts to reduce inflammation and support your pain-fighting gut microbiome • move better, at home and at work, to release natural neurochemical painkillers • recharge and recover through sleep, mindfulness, stress reduction, and supportive social relationships More than just a road map to less pain, this is a guide to the greater joy, health, and well-being that every person deserves.
Cancer and Aging
Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. Core examples of these close associations are addressed in this book. Starting with basic research, the first chapters cover cancer development, mTOR inhibition, senescent cells altering the tumor microenvironment, and immune senescence affecting cancer vaccine response. Taking into account the multidisciplinarity of geriatric oncology, several chapters focus on geriatric and oncologic aspects in patient assessment, treatment option...
Handbook of Mitochondrial Dysfunction
Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.
Geriatric Oncology
This book is intended as a comprehensive resource for clinicians and researchers seeking in-depth information on geriatric oncology. The coverage encompasses epidemiology, the biology and (patho)physiology of aging and cancer, geriatric assessment and management, hematologic malignancies, solid tumors, issues in patient care, and research methods. Since cancer is a disease of aging and people are living longer, most cancer patients are now aged 70 and older. Yet the more we age, the more diverse we become in terms of our health, biologic fitness, and cancer behavior. Typically, however, general oncology clinical trials address only a selected healthier and younger population of patients. Ger...
