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Aqueous Two-Phase Systems for Bioprocess Development for the Recovery of Biological Products
This comprehensive and unique text presents a full overview of downstream processing useful for those new to the concept as well as professionals with experience in the area. The history and theoretical principles of Aqueous Two-Phase Systems (ATPS) are covered in depth. Information on ATPS characterization and application is included, and ATPS equilibria and system parameters that have significant effect on partition behavior are studied. Aqueous Two-Phase Systems for Bioprocess Development for the Recovery of Biological Products addresses specific applications of ATPS for the recovery and partial purification of high molecular weight compounds such as proteins, nucleic acids and polysaccha...
Bio-Inspired Strategies for Modeling and Detection in Diabetes Mellitus Treatment
Bio-Inspired Strategies for Modeling and Detection in Diabetes Mellitus Treatment focuses on bio-inspired techniques such as modelling to generate control algorithms for the treatment of diabetes mellitus. The book addresses the identification of diabetes mellitus using a high-order recurrent neural network trained by the extended Kalman filter. The authors also describe the use of metaheuristic algorithms for the parametric identification of compartmental models of diabetes mellitus widely used in research works such as the Sorensen model and the Dallaman model. In addition, the book addresses the modelling of time series for the prediction of risk scenarios such as hyperglycaemia and hypog...
Enzyme-linked Immunosorbent Assay (ELISA)
This book offers comprehensive information on all aspects of ELISA, starting with the fundamentals of the immune system. It also reviews the history of analytical assays prior to the advent of ELISA (enzyme-linked immunosorbent assay) and addresses the materials of choice for the fabrication of the platforms, possible biomolecular interactions, different protocols, and evaluation parameters. The book guides readers through the respective steps of the analytical assay, while also familiarizing them with the possible sources of error in the assay. It offers detailed insights into the immobilization techniques used for protein attachment, as well as methods for evaluating the assay and calculat...
Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics
Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. - Covers the vital new area of R&D on therapeutic antibodies - Written by leading scientists and researchers - Up-to-date coverage and includes a detailed bibliography
The Science and Application of Aqueous Two-Phase Systems and Liquid-Liquid Phase Separation in Biotechnology and Bioengineering
The phase separation of incompatible liquids has been a topic of significant importance in chemical and industrial engineering for many years. Well-understood examples of this phenomenon include the phase separation of oil with water and the phase separation of non-polar organic solvents with water. Similar behavior is observed when aqueous solutions of two or more incompatible polymers or polymers and salts are mixed. In these mixtures (referred to as aqueous two-phase systems), the separated phases are composed mostly of water. Aqueous two-phase systems have been used extensively for the extraction of high-value biological products from mixtures of biological materials. In recent years, aqueous two-phase systems have also found increased use as materials for streamlining and improving the capabilities of cell and molecular assays, and for the design of advanced cell culture systems. Similar behavior of biological materials in living systems has also been observed, with emerging roles in cell physiology.
Phycology-Based Approaches for Wastewater Treatment and Resource Recovery
Algal and phycology-based approaches for wastewater treatment have recently gained interest. Phycology-Based Approaches for Wastewater Treatment and Resource Recovery highlights advanced algal-based technologies developed or being considered for wastewater treatment along with the opportunities that existing technologies can provide at an industrial scale. It covers recent findings on algal-based approaches for the removal of heavy metals, organic pollutants, and other toxicities from sewage and industrial effluents and supplies in-depth analysis on technologies such as biosorption and bioaccumulations. Advanced mathematical modeling approaches to understand waste removal and resource recove...
Biopharmaceutical Processing
Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry. The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies related to downstream purification and upstream processing fields. Economic considerations are included throughout, with recommendations for lowering costs and improving efficiencies. Designed for quick reference and easy accessibility of facts, calculations and guidelines, this book is an essential tool for industrial scientists and managers in the biopharmaceutical industry. - Offers a comprehensive, go-to reference for daily work decisions - Covers both upstream and downstream processes - Includes case studies that emphasize financial outcomes - Presents summaries, decision grids, graphs and overviews for quick reference
