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Renaissance Fun
Renaissance Fun is about the technology of Renaissance entertainments in stage machinery and theatrical special effects; in gardens and fountains; and in the automata and self-playing musical instruments that were installed in garden grottoes. How did the machines behind these shows work? How exactly were chariots filled with singers let down onto the stage? How were flaming dragons made to fly across the sky? How were seas created on stage? How did mechanical birds imitate real birdsong? What was ‘artificial music’, three centuries before Edison and the phonograph? How could pipe organs be driven and made to play themselves by waterpower alone? And who were the architects, engineers, an...
Lessing Yearbook Index to Volumes I-XX and the Supplements
This volume is a register and bibliography to the first 20 volumes of the Lessing Yearbook and its supplements, Humanitaet und Dialog, Lessing in heutiger Sicht, Nation und Gelehrtenrepublik, and Lessing und die Toleranz.
Surrogate Endpoints in Medicine
A review of the use of surrogate endpoints and biomarkers in drug development, validation and qualification of biomarkers, pharmacogenic biomarkers, and novel approaches to biomarker discovery. It also discusses specific biomarkers including QTc prolongation and biomarkers of early stage cancer.
The Craft of Thought
The Craft of Thought, first published in 1998, is a companion to Mary Carruthers' earlier study of memory in medieval culture, The Book of Memory. This more recent volume examines medieval monastic meditation as a discipline for making thoughts, and discusses its influence on literature, art, and architecture. In a process akin to today's 'creative' thinking, or 'cognition', this discipline recognises the essential roles of imagination and emotion in meditation. Deriving examples from a variety of late antique and medieval sources, with excursions into modern architectural memorials, this study emphasises meditation as an act of literary composition or invention, the techniques of which notably involved both words and making mental 'pictures' for thinking and composing.
The Mitochondrion in Aging and Disease
Mitochondria, the "power plants" of eukaryotic cells, are best known for the generation of adenosine triphosphate (ATP), the universal cellular "energy currency" of the cell, and the synthesis of different essential components. Mitochondrial dysfunction is known to lead to various degenerative disorders, disease, and aging. The Mitochondrion in Aging and Disease works to unravel the processes leading to mitochondrial impairments and of pathways involved in mitochondrial quality control and their impact on health and aging will be addressed. - Reviews current topics of interest - Written by experts in the field
Neuropsychology and Neuropsychiatry of Neurodegenerative Disorders
This book compiles all articles within the Research Topic "Neuropsychology and neuropsychiatry of neurodegenerative disorders" published in the journal Frontiers in Aging Neuroscience. The call was launched in 2014 and closed in 2015 with 21 articles published. Papers deal on several important topics of neuropsychology -such as language and visuospatial functions- and neuropsychiatry - such us the emotional or motivational spheres - , and the interphase between them. There are also articles on psychometry, brain morphometry, brain connectivity, diagnostic tests and interventional studies. All these articles are focused on neurodegenerative conditions, mostly Alzheimer’s disease and Parkinson’s disease. Interestingly, several articles addressed the early stages of these diseases. All together, this Research Topic provides a rich perspective of the research made today around neuropsychological and neuropsychiatric aspects of neurodegenerative diseases. We hope readers enjoy this collection of articles.
The Symphonic Repertoire, Volume I
Central to the repertoire of Western art music since the 18th century, the symphony has come to be regarded as one of the ultimate compositional challenges. In his five-volume series The Symphonic Repertoire, the late A. Peter Brown explores the symphony from its 18th-century beginnings to the end of the 20th century. In Volume 1, The Eighteenth-Century Symphony, 22 of Brown's former students and colleagues collaborate to complete the work that he began on this critical period of development in symphonic history. The work follows Brown's outline, is organized by country, and focuses on major composers. It includes a four-chapter overview and concludes with a reframing of the symphonic narrative. Contributors address issues of historiography, the status of research, and questions of attribution and stylistic traits, and provide background material on the musical context of composition and early performances. The volume features a CD of recordings from the Bloomington Early Music Festival Orchestra, highlighting the largely unavailable repertoire discussed in the book.
Leptomeningeal Metastases
A review of state-of-the-art therapies currently used with leptomeningeal cancer patients, including information on symptom management, new clinical trials, epidemiology, as well as research in animal models for experimental treatments.
