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Multiparameter Flow Cytometry in the Diagnosis of Hematologic Malignancies
This practical manual offers an active understanding of how to implement flow-cytometry when facing complex, haematological diseases.
Multiparameter Flow Cytometry in the Diagnosis of Hematologic Malignancies
Master implementation of the techniques of flow cytometry in diagnosing complex haematological diseases and malignancies in patients, worldwide. Featuring World Health Organization recommendations on pre-analytical steps, instrument settings and panel construction, this invaluable manual offers invaluable support for those researching, practising and analyzing the cause of hematological malignancies. Authored by leading experts, this book puts flow-cytometry into everyday context. With a focus on multicolour panels, the manual provides readers an experienced understanding of effective, implementation techniques. Practitioners of all levels are offered a background in a variety of diseases presented alongside the most current methodology. Wide-ranging and comprehensive; detailed images of healthy blood, bone marrow and lymph-nodes are illustrated throughout, allowing for effective diagnosis. Through engaging with differential diagnoses, the manual offers an understanding of similar symptoms and mimicking malignancies, avoiding inaccurate results. Featuring in-depth descriptions of chronic diseases; users can reach accurate diagnosis, first time.
IgA Nephropathy
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The Evo-Devo Origin of the Nose, Anterior Skull Base and Midface
The phylontogenic theory proposes an original understanding of nose, sinus and midface formation and development by looking back in evolution for the first traces of the olfactory organ and then tracing its successive phyletic transformations to become part of the respiratory apparatus and finally the central point of human facial anatomy. Von Baer’s, Darwin’s, Haeckel’s, Garstang’s, Gould’s and Buss’ explorations of parallels between phylogeny and ontogeny help to trace the nose and midface story. The paradigm of existing parallels between ontogeny and phylogeny proves useful both in seeking to understand the holoprosencephalic spectrum of facial malformations (which represent radically different pathways of facial development after the life’s tape has been started to run again) and in formulating hypotheses on chordate to vertebrate evolution. The phylontogenic theory leads to new medical hypotheses on nose and sinus diseases and opens the field of evolution and development-based medicine.
Immunophenotyping of Blood and Bone Marrow Leukocytes
Significant improvements in the leukocytes immunophenotypic characterisation have given rise to numerous medical applications in the haematological and immunological fields. This book is designed to give the biologist all the necessary information needed to select and conduct a test correctly, and to interpret the result. Thus, it will improve the communication between the biologist and the clinician which will enable the clinician to have increased confidence in the test.
The Origin of the Plasma Cell Heterogeneity
Plasma cells (PCs) are terminally differentiated B-cells producing large amounts of immunoglobulins (Ig). In humans, most of circulating Ig are produced by bone marrow plasma cells. PCs differentiate from activated naïve or memory B-cells usually activated by specific antigens. It is still controversial whether the regulation of PCs numbers and the “active” in vivo Ig diversity depend or not on non-specific reactivation of B-cells during infections. Depending on the stimulus (T-independent/T-dependent antigen, cytokines, partner cells) and B-cell types (naïve or memory, circulating or germinal center, lymph nodes or spleen, B1 or B2...), both the phenotype and isotype of PCs differ suggesting that PC diversity is either linked to B-cell diversity or to the type of stimulus or to both. Knowledge of the mechanisms supporting PC diversity has important consequences for the management of i) plasma cell neoplasia such as Multiple Myeloma and Waldenström's Macroglobulinemia, ii) vaccine protection against pathogens and iii) auto-immune diseases.
Vaccins
Les séminaires d'Immunologie clinique et Allergologie sont organisés chaque année dans le cadre de la formation médicale continue des Hospices Civils de Lyon. Ils comportent une partie sur les récents développements en immunologie fondamentale utile pour la compréhension des maladies inflammatoires, allergiques et auto-immunes et une partie sur un thème spécifique à l'allergie médicamenteuse. Le thème retenu pour ce séminaire est l'intolérance et l'allergie aux vaccins. Ces mises au point sur les notions les plus récentes de la recherche sont indispensables aux médecins, chercheurs et professionnels de la santé intéressés par l'immunologie clinique, l'intolérance médicamenteuse et l'allergologie.
Autoimmunity and the Thyroid
Autoimmunity and the Thyroid is a collection of papers presented at an International Satellite Meeting prior to the 7th International Congress of Endocrinology, held at the Mount Sinai Hospital, University of Toronto Medical School on June 29 and 30, 1984. The book provides presentations of participants relating to selected aspects of immune regulation and its role in autoimmune thyroid diseases. Concepts on humoral and cell-mediated immunity mechanisms in the pathogenesis of autoimmune thyroid disease are reviewed; important observations with promising clinical implications in terms of immunogenetics of Graves' and Hashimoto's diseases are presented; and selection of appropriate therapy for Graves' thyrotoxicosis, and the possibility of preventive immunosuppressive and ophthalmopathy therapy are discussed. Endocrinologists, physicians, pathologists, physiologists, and medical researchers will find the book interesting.
Guide des analyses en hématologie
L'ouvrage Ce guide, rédigé par la SFH recense les principales analyses en hématologie prises en charge par la Sécurité sociale dans le cadre de la nomenclature des actes de biologie médicale (NABM) ou du référentiel des actes innovants hors nomenclature (RIHN). L'ouvrage développe en 4 grandes parties l'exploration : – de la cytologie : tests généraux ; – de l'hémostase et de la coagulation ; – de l'immunohématologie ; – de l'oncologie moléculaire hématologique. Chacune de ces parties est détaillée de façon pratique et synthétique sous forme de fiches, étayées de synopsis d'aide à l'exploration de la pathologie. Les points suivants sont systématiquement abordé...
